MicroRNA‐9 inhibits growth and invasion of head and neck cancer cells and is a predictive biomarker of response to plerixafor, an inhibitor of its target CXCR4
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12352
Abstract: Head and neck squamous cell carcinomas (HNSCC) are associated with poor morbidity and mortality. Current treatment strategies are highly toxic and do not benefit over 50% of patients. There is therefore a crucial need for… read more here.
Keywords: biomarker; hnscc; cell; head neck ... See more keywords
A prognostic mRNA expression signature of four 16q24.3 genes in radio(chemo)therapy‐treated head and neck squamous cell carcinoma (HNSCC)
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12388
Abstract: Previously, we have shown that copy number gain of the chromosomal band 16q24.3 is associated with impaired clinical outcome of radiotherapy‐treated head and neck squamous cell carcinoma (HNSCC) patients. We set out to identify a… read more here.
Keywords: cell; chemo therapy; hnscc; signature ... See more keywords
Clinical significance of FAT1 gene mutation and mRNA expression in patients with head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13171
Abstract: The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of FAT1 in head and neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts… read more here.
Keywords: fat1 gene; hnscc; significance fat1; clinical significance ... See more keywords
HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway
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DOI: 10.1002/advs.202202437
Abstract: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck, and the prognosis of patients is poor due to chemotherapeutic resistance. Interestingly, patients with HNSCC induced by… read more here.
Keywords: anemia pathway; hpv; serpinb3 expression; hnscc ... See more keywords
Ferroptosis Signature Shapes the Immune Profiles to Enhance the Response to Immune Checkpoint Inhibitors in Head and Neck Cancer
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DOI: 10.1002/advs.202204514
Abstract: As a type of immunogenic cell death, ferroptosis participates in the creation of immunoactive tumor microenvironments. However, knowledge of spatial location of tumor cells with ferroptosis signature in tumor environments and the role of ferroptotic… read more here.
Keywords: head neck; ferroptosis signature; hnscc; immune ... See more keywords
Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD‐L1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1529
Abstract: Head and neck squamous cell carcinoma (HNSCC) ranks among the top most common cancers with a poor prognosis. The mechanism of chemoresistance is still not well known. This study is to investigate the programmed death‐ligand… read more here.
Keywords: cisplatin resistant; resistant hnscc; hnscc cells; hnscc ... See more keywords
COL3A1: Potential prognostic predictor for head and neck cancer based on immune‐microenvironment alternative splicing
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5170
Abstract: We aimed to identify a novel prognostic biomarker for head and neck squamous cell carcinoma (HNSCC) based on tumor immunology‐related alternative splicing (AS). Data for 502 HNSCC and 44 normal samples were obtained from the… read more here.
Keywords: head neck; prognostic predictor; expression; alternative splicing ... See more keywords
Cancer cell‐derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5601
Abstract: It recently has been reported that partial‐epithelial–mesenchymal transition (p‐EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion‐promoting molecule in… read more here.
Keywords: cell; postn; iso5; isoform ... See more keywords
TRAF3/CYLD mutations identify a distinct subset of human papillomavirus‐associated head and neck squamous cell carcinoma
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DOI: 10.1002/cncr.30570
Abstract: The incidence of human papillomavirus (HPV)‐associated (HPV‐positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV‐positive HNSCCs in the United… read more here.
Keywords: neck squamous; hnscc; hpv; human papillomavirus ... See more keywords
Immunohistochemical detection of lymph node‐DTCs in patients with node‐negative HNSCC
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DOI: 10.1002/ijc.30617
Abstract: This study was performed to systematically assess the prevalence, topography and prognostic impact of disseminated tumor cells (DTCs) in lymph nodes (LN) of patients with primary, regional and distant metastasis‐free head and neck squamous cell… read more here.
Keywords: dtcs patients; immunohistochemical detection; hnscc; elective neck ... See more keywords
Endoscopic screening for synchronous esophageal neoplasia among patients with incident head and neck cancer: Prevalence, risk factors, and outcomes
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DOI: 10.1002/ijc.30911
Abstract: Esophageal squamous‐cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head‐and‐neck squamous‐cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in… read more here.
Keywords: neoplasia; risk factors; hnscc; cancer ... See more keywords