Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD‐L1
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1529
Abstract: Head and neck squamous cell carcinoma (HNSCC) ranks among the top most common cancers with a poor prognosis. The mechanism of chemoresistance is still not well known. This study is to investigate the programmed death‐ligand… read more here.
Keywords: cisplatin resistant; resistant hnscc; hnscc cells; hnscc ... See more keywords
Head and neck tumor cells treated with hypofractionated irradiation die via apoptosis and are better taken up by M1-like macrophages
Sign Up to like & getrecommendations! Published in 2021 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-021-01856-4
Abstract: The incidence of head and neck squamous cell carcinomas (HNSCC) is increasing worldwide, especially when triggered by the human papilloma virus (HPV). Radiotherapy has immune-modulatory properties, but the role of macrophages present in HNSCC and… read more here.
Keywords: cells treated; hnscc cells; tumor cells; treated hypofractionated ... See more keywords
Metformin enhances gefitinib efficacy by interfering with interactions between tumor-associated macrophages and head and neck squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00446-y
Abstract: BackgroundTumor-associated macrophages (TAMs) play an important role in drug resistance in many tumors, including head and neck squamous cell carcinoma (HNSCC). However, how TAMs interact with HNSCC cells to induce drug resistance, especially under hypoxic… read more here.
Keywords: hnscc cells; hnscc; resistance; associated macrophages ... See more keywords
Differential anticancer activities of arsenic trioxide on head and neck cancer cells with different human papillomavirus status
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.033
Abstract: Aims: Approximately 20% of head and neck squamous cell carcinomas (HNSCCs) are caused by human papillomavirus (HPV) infection. The effect of arsenic trioxide (ATO) on HPV oncogene expression of HNSCC cells remains unknown. In this… read more here.
Keywords: hnscc cells; hnscc; expression; hpv positive ... See more keywords
Abstract 2832: Plk1 signaling as a therapeutic target for HPV- head and neck cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2832
Abstract: Current frontline chemotherapy and radiotherapy for head and neck cancer (HNC) is insufficient as ~60% of patients relapse within two years, indicating a need to identify novel targeted therapies to improve survival outcomes for HNC… read more here.
Keywords: plk1; hnscc; hnscc cells; cancer ... See more keywords
PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.21277
Abstract: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high… read more here.
Keywords: apr 246; hnscc cells; trxr1; inactivation ... See more keywords
Regulatory Role of Hexokinase 2 in Modulating Head and Neck Tumorigenesis
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DOI: 10.3389/fonc.2020.00176
Abstract: To support great demand of cell growth, cancer cells preferentially obtain energy and biomacromolecules by glycolysis over mitochondrial oxidative phosphorylation (OxPhos). Among all glycolytic enzymes, hexokinase (HK), a rate-limiting enzyme at the first step of… read more here.
Keywords: neck tumorigenesis; hnscc cells; cell; head neck ... See more keywords
Differential Angiogenic Potential of 3-Dimension Spheroid of HNSCC Cells in Mouse Xenograft
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158245
Abstract: The experimental animal model is still essential in the development of new anticancer drugs. We characterized mouse tumors derived from two-dimensional (2D) monolayer cells or three-dimensional (3D) spheroids to establish an in vivo model with… read more here.
Keywords: spheroid; monolayer; differential angiogenic; hnscc cells ... See more keywords