Dual pathways of tRNA hydroxylation ensure efficient translation by expanding decoding capability
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DOI: 10.1038/s41467-019-10750-8
Abstract: In bacterial tRNAs, 5-carboxymethoxyuridine (cmo5U) and its derivatives at the first position of the anticodon facilitate non-Watson–Crick base pairing with guanosine and pyrimidines at the third positions of codons, thereby expanding decoding capabilities. However, their… read more here.
Keywords: trna hydroxylation; expanding decoding; efficient translation; ho5u formation ... See more keywords