Utilizing single- and double-transfected cell models expressing human organic anion transporter 1 and human cytochrome P450 1A2 to investigate the interactions with ingredients of herbal medicines
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DOI: 10.1080/00498254.2016.1211774
Abstract: Abstract 1. Cell models expressing human drug transporters and enzymes are useful tools to understand the process of drug disposition in vitro. However, no study on transfected cells stably co-expressing human organic anion transporter 1 (hOAT1)… read more here.
Keywords: hoat1 hcyp1a2; expressing human; cell models; hoat1 ... See more keywords
PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1
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DOI: 10.1124/dmd.117.075861
Abstract: Human organic anion transporter-1 (hOAT1) regulates the absorption, distribution, and excretion of a wide range of clinically important drugs. Our previous work demonstrated that hOAT1 is a dynamic membrane transporter, constitutively internalizing from and recycling… read more here.
Keywords: transporter hoat1; pkc; hoat1; expression ... See more keywords