A Case Series Assessing the Effects of Lomitapide on Carotid Intima-Media Thickness in Adult Patients with Homozygous Familial Hypercholesterolaemia in a Real-World Setting
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DOI: 10.1007/s12325-021-02031-y
Abstract: Homozygous familial hypercholesterolaemia (HoFH) is characterised by extremely elevated levels of low-density lipoprotein cholesterol (LDL-C) and results from multiple mutations in genes affecting the LDL receptor pathway. Patients are at risk of premature atherosclerotic cardiovascular… read more here.
Keywords: media thickness; familial hypercholesterolaemia; carotid intima; hofh ... See more keywords
Efficacy and Safety of Lomitapide in Hypercholesterolemia
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DOI: 10.1007/s40256-017-0214-7
Abstract: BackgroundDespite extensive use of statins, patients with hypercholesterolemia, especially homozygous familial hypercholesterolemia (HoFH), do not achieve recommended targets of low-density lipoprotein cholesterol (LDL-C). There is an urgent need for novel options that could reduce proatherogenic… read more here.
Keywords: hofh; hypercholesterolemia; efficacy safety; cholesterol ... See more keywords
Quality of life and coping in Dutch homozygous familial hypercholesterolemia patients: A qualitative study.
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DOI: 10.1016/j.atherosclerosis.2022.03.015
Abstract: BACKGROUND AND AIMS Homozygous familial hypercholesterolemia (HoFH) is characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels leading to extremely premature atherosclerotic cardiovascular disease. Therefore, healthcare professionals consider HoFH to have major impact on patients'… read more here.
Keywords: quality life; hofh; homozygous familial; familial hypercholesterolemia ... See more keywords
Will evinacumab become the standard treatment for homozygous familial hypercholesterolemia?
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DOI: 10.1080/14712598.2021.1862083
Abstract: ABSTRACT Introduction: Homozygous Familial Hypercholesterolemia (HoFH) is a very severe genetic form of hypercholesterolemia. Lacking LDL receptors in the liver, subjects with HoFH have raised plasma levels of LDL cholesterol, and up to 100 times… read more here.
Keywords: hofh; hypercholesterolemia; treatment; cholesterol ... See more keywords
Aortic stenosis in homozygous familial hypercholesterolaemia: a paradigm shift over a century.
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DOI: 10.1093/eurheartj/ehac339
Abstract: AIMS Homozygous familial hypercholesterolaemia (HoFH) is an orphan disease defined by extreme elevations in low-density lipoprotein cholesterol, cutaneous xanthomas, and pre-mature atherosclerotic cardiovascular disease. Survival has more than doubled over the past three decades. Aortic… read more here.
Keywords: familial hypercholesterolaemia; hofh; aortic stenosis; homozygous familial ... See more keywords
Case Report: Liver Transplantation in Homozygous Familial Hypercholesterolemia (HoFH)—Long-Term Follow-Up of a Patient and Literature Review
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DOI: 10.3389/fped.2020.567895
Abstract: Homozygous familial hypercholesterolemia (HoFH) is a rare inherited metabolic disorder, frequently leading to an early cardiovascular death if not adequately treated. Since standard medications usually fail to reduce LDL-cholesterol (LDL-C) levels satisfactorily, LDL-apheresis is a… read more here.
Keywords: hofh; hypercholesterolemia hofh; liver transplantation; familial hypercholesterolemia ... See more keywords
A First-in-Class Drug, Lomitapide, Tailored to Patients with Homozygous Familial Hypercholesterolemia is Just about Meeting with Good News to Them
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.ed069
Abstract: A raised low-density lipoprotein (LDL) cholesterol (LDL-C) is one of the major risk factors for atherosclerotic cardiovascular disease (ASCVD) . Homozygous family hypercholesterolemia (HoFH) is a rare inherited disease characterized by markedly elevated levels of… read more here.
Keywords: hofh; hypercholesterolemia; ldl; target ... See more keywords