Enantioselective Synthesis of Nicotine via an Iodine-Mediated Hofmann-Löffler Reaction.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.8b03909
Abstract: An iodine-mediated Hofmann-Löffler reaction has been developed that enables the first enantioselective synthesis of nicotine based on this synthetic methodology. The effect of the free pyridine core on the involved electrophilic iodine reagents was explored… read more here.
Keywords: mediated hofmann; iodine mediated; hofmann ffler; iodine ... See more keywords