Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors.
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DOI: 10.1021/acsmedchemlett.8b00406
Abstract: β-N-Acetylhexosaminidases are widely distributed exoglycosidases and have attracted significant attention due to their important roles in the field of pesticide and drug discovery. Remarkably, human O-GlcNAcase (hOGA) and human β-N-acetylhexosaminidase (HsHex) possess the same catalytic… read more here.
Keywords: hoga; thioglycosyl naphthalimides; human glcnacase; naphthalimides potent ... See more keywords