Construction of a Holliday Junction in Small Circular DNA Molecules for Stable Motifs and Two‐Dimensional Lattices
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DOI: 10.1002/cbic.201800122
Abstract: Design rules for DNA nanotechnology have been mostly learnt from using linear single‐stranded (ss) DNA as the source material. For example, the core structure of a typical DAO (double crossover, antiparallel, odd half‐turns) tile for… read more here.
Keywords: small circular; dna; holliday junction; nanotechnology ... See more keywords
Atomistic Picture of Opening–Closing Dynamics of DNA Holliday Junction Obtained by Molecular Simulations
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DOI: 10.1021/acs.jcim.3c00358
Abstract: Holliday junction (HJ) is a noncanonical four-way DNA structure with a prominent role in DNA repair, recombination, and DNA nanotechnology. By rearranging its four arms, HJ can adopt either closed or open state. With enzymes… read more here.
Keywords: picture opening; dna; holliday junction; atomistic picture ... See more keywords
Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123420119
Abstract: Significance We devised a method involving DNAzyme self-cleavage for the preparation of DNA molecules containing double Holliday junctions (dHJs) that are separated by 746 bp. The DNAs can be prepared in large amounts suitable for… read more here.
Keywords: generation double; holliday junction; junction dnas; resolution ... See more keywords
Holliday junction resolution by At-HIGLE: an SLX1 lineage endonuclease from Arabidopsis thaliana with a novel in-built regulatory mechanism.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac239
Abstract: Holliday junction is the key homologous recombination intermediate, resolved by structure-selective endonucleases (SSEs). SLX1 is the most promiscuous SSE of the GIY-YIG nuclease superfamily. In fungi and animals, SLX1 nuclease activity relies on a non-enzymatic… read more here.
Keywords: holliday junction; higle; slx1 lineage; arabidopsis thaliana ... See more keywords
Cryo-EM structure of the RuvAB-Holliday junction intermediate complex from Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2023.1139106
Abstract: Holliday junction (HJ) is a four-way structured DNA intermediate in homologous recombination. In bacteria, the HJ-specific binding protein RuvA and the motor protein RuvB together form the RuvAB complex to catalyze HJ branch migration. Pseudomonas… read more here.
Keywords: cryo structure; structure; pseudomonas aeruginosa; holliday junction ... See more keywords