Holo Protein Conformation Generation from Apo Structures by Ligand Binding Site Refinement
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00895
Abstract: An important part in structure-based drug design is the selection of an appropriate protein structure. It has been revealed that a holo protein structure that contains a well-defined binding site is a much better choice… read more here.
Keywords: structure; holo; binding site; apo structures ... See more keywords
AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.09.05.496878
Abstract: Understanding the mechanism of action of a protein or designing better ligands for it often requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for the quick and easy… read more here.
Keywords: apo holo; holo; defined ligands; user defined ... See more keywords
Extraintestinal Pathogenic Escherichia coli Utilizes Surface-Located Elongation Factor G to Acquire Iron from Holo-Transferrin
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DOI: 10.1128/spectrum.01662-21
Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) is an important pathogen causing systemic infections in humans and animals. The competition for iron between ExPEC and the host is a determinant for ExPEC to establish a successful infection.… read more here.
Keywords: expec; iron; escherichia coli; holo ... See more keywords
Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
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DOI: 10.18632/oncotarget.6463
Abstract: Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at… read more here.
Keywords: holo omes; holo; constructing personalized; colon cancer ... See more keywords