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   Articles with "holo" as a keyword



Holo Protein Conformation Generation from Apo Structures by Ligand Binding Site Refinement

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recommendations! Published in 2022 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.2c00895

Abstract: An important part in structure-based drug design is the selection of an appropriate protein structure. It has been revealed that a holo protein structure that contains a well-defined binding site is a much better choice… read more here.

Keywords: structure; holo; binding site; apo structures ... See more keywords

AHoJ: rapid, tailored search and retrieval of apo and holo protein structures for user-defined ligands

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recommendations! Published in 2022 at "Bioinformatics"

DOI: 10.1101/2022.09.05.496878

Abstract: Understanding the mechanism of action of a protein or designing better ligands for it often requires access to a bound (holo) and an unbound (apo) state of the protein. Resources for the quick and easy… read more here.

Keywords: apo holo; holo; defined ligands; user defined ... See more keywords

Extraintestinal Pathogenic Escherichia coli Utilizes Surface-Located Elongation Factor G to Acquire Iron from Holo-Transferrin

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recommendations! Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01662-21

Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) is an important pathogen causing systemic infections in humans and animals. The competition for iron between ExPEC and the host is a determinant for ExPEC to establish a successful infection.… read more here.

Keywords: expec; iron; escherichia coli; holo ... See more keywords

Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice

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recommendations! Published in 2019 at "Oncotarget"

DOI: 10.18632/oncotarget.6463

Abstract: Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at… read more here.

Keywords: holo omes; holo; constructing personalized; colon cancer ... See more keywords

AlphaFold2-Based Characterization of Apo and Holo Protein Structures and Conformational Ensembles Using Randomized Alanine Sequence Scanning Adaptation: Capturing Shared Signature Dynamics and Ligand-Induced Conformational Changes

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms252312968

Abstract: Proteins often exist in multiple conformational states, influenced by the binding of ligands or substrates. The study of these states, particularly the apo (unbound) and holo (ligand-bound) forms, is crucial for understanding protein function, dynamics,… read more here.

Keywords: alanine sequence; holo; protein; randomized alanine ... See more keywords