Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110168
Abstract: Neuronal CaMKII holoenzymes (α and β isoforms) enable molecular signal computation underlying learning and memory but also mediate excitotoxic neuronal death. Here, we provide a comparative analysis of these signaling devices, using single-particle electron microscopy… read more here.
Keywords: high order; holoenzyme; neuronal camkii; conserved divergent ... See more keywords
Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Research"
DOI: 10.1038/s41422-022-00620-2
Abstract: Methanobactins (Mbns) are a family of copper-binding peptides involved in copper uptake by methanotrophs, and are potential therapeutic agents for treating diseases characterized by disordered copper accumulation. Mbns are produced via modification of MbnA precursor… read more here.
Keywords: mechanism mbnbc; mbnbc holoenzyme; catalytic mechanism; holoenzyme ... See more keywords
Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10496-3
Abstract: Ribonuclease P (RNase P) is an essential ribozyme responsible for tRNA 5′ maturation. Here we report the cryo-EM structures of Methanocaldococcus jannaschii (Mja) RNase P holoenzyme alone and in complex with a tRNA substrate at… read more here.
Keywords: structure archaeal; microscopy; ribonuclease; rnase ... See more keywords
PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00104-23
Abstract: Toxoplasma gondii switches back and forth between acute and chronic infections, mainly in response to host immunologic status, which is characterized by flexible but specific energy metabolism. Polysaccharide granules are accumulated in the acute infection… read more here.
Keywords: metabolism; gondii; toxoplasma gondii; pp2ac pr61 ... See more keywords