Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00430
Abstract: Plant homeodomain finger protein 1 (PHF1) is an accessory component of the gene silencing complex polycomb repressive complex 2 and recognizes the active chromatin mark, trimethylated lysine 36 of histone H3 (H3K36me3). In addition to… read more here.
Keywords: plant homeodomain; protein phf1; homeodomain finger; finger protein ... See more keywords
Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00611
Abstract: The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here, we describe NI-57 (16) as new pan-BRPF chemical probe of… read more here.
Keywords: plant homeodomain; finger containing; bromodomain plant; family ... See more keywords
Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000588
Abstract: PURPOSE OF REVIEW Even though an increasing amount of sequencing data on the leukemia genome has highlighted a tumor-suppressive function for plant homeodomain finger protein 6 (PHF6), its role in the hematopoietic system remained elusive… read more here.
Keywords: phf6; homeodomain finger; plant homeodomain; finger protein ... See more keywords