Homeodomain Proteins Directly Regulate ATM Kinase Activity
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.089
Abstract: SUMMARY Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress. NKX3.1, a prostate-specific transcription factor, was recently shown to directly stimulate ATM kinase activity through its… read more here.
Keywords: kinase activity; kinase; homeodomain proteins; atm kinase ... See more keywords
Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad318
Abstract: Homeodomain proteins constitute one of the largest families of metazoan transcription factors. Genetic studies have demonstrated that homeodomain proteins regulate many developmental processes. Yet, biochemical data reveal that most bind highly similar DNA sequences. Defining… read more here.
Keywords: selex data; homeodomain; dna binding; high throughput ... See more keywords