Impaired purine homeostasis plays a primary role in trimethoprim‐mediated induction of virulence genes in Burkholderia thailandensis
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DOI: 10.1111/mmi.14626
Abstract: One of the most commonly prescribed antibiotics against Burkholderia infections is co‐trimoxazole, a cocktail of trimethoprim and sulfamethoxazole. Trimethoprim elicits an upregulation of the mal gene cluster, which encodes proteins involved in synthesis of the… read more here.
Keywords: trimethoprim; purine homeostasis; virulence; homeostasis plays ... See more keywords