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   Articles with "homeostatic plasticity" as a keyword



A presynaptic phosphosignaling hub for lasting homeostatic plasticity.

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recommendations! Published in 2022 at "Cell reports"

DOI: 10.1016/j.celrep.2022.110696

Abstract: Stable function of networks requires that synapses adapt their strength to levels of neuronal activity, and failure to do so results in cognitive disorders. How such homeostatic regulation may be implemented in mammalian synapses remains… read more here.

Keywords: phosphosignaling hub; rim1; homeostatic plasticity; presynaptic phosphosignaling ... See more keywords

Disruption of cortical synaptic homeostasis in individuals with chronic low back pain

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recommendations! Published in 2018 at "Clinical Neurophysiology"

DOI: 10.1016/j.clinph.2018.01.060

Abstract: OBJECTIVE Homeostatic plasticity mechanisms regulate synaptic plasticity in the human brain. Impaired homeostatic plasticity may contribute to maladaptive synaptic plasticity and symptom persistence in chronic musculoskeletal pain. METHODS We examined homeostatic plasticity in fifty individuals… read more here.

Keywords: individuals chronic; tdcs; homeostatic plasticity; chronic low ... See more keywords
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Presynaptic Homeostatic Plasticity Staves off Neurodegenerative Pathophysiology up to a Tipping Point

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recommendations! Published in 2020 at "Neuron"

DOI: 10.1016/j.neuron.2020.06.013

Abstract: In this issue of Neuron, Orr et al. (2020) identify an evolutionarily conserved mechanism of presynaptic homeostatic plasticity induced by ALS-like motor neuron degeneration, which maintains excitatory potentials until a threshold of synaptic loss is reached.… read more here.

Keywords: homeostatic plasticity; tipping point; plasticity staves; presynaptic homeostatic ... See more keywords

No neuron is an island: Homeostatic plasticity and over-constraint in a neural circuit

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recommendations! Published in 2020 at "Neurobiology of Learning and Memory"

DOI: 10.1016/j.nlm.2019.01.005

Abstract: To support computation the activity of neurons must vary within a useful range, which highlights one potential value of homeostatic plasticity. The interconnectedness of the brain, however, introduces the possibility that combinations of homeostatic mechanisms… read more here.

Keywords: neuron island; plasticity constraint; homeostatic plasticity; island homeostatic ... See more keywords

Enhancing excitatory activity of somatosensory cortex alleviates neuropathic pain through regulating homeostatic plasticity

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-12972-6

Abstract: Central sensitization and network hyperexcitability of the nociceptive system is a basic mechanism of neuropathic pain. We hypothesize that development of cortical hyperexcitability underlying neuropathic pain may involve homeostatic plasticity in response to lesion-induced somatosensory… read more here.

Keywords: excitatory activity; homeostatic plasticity; somatosensory cortex; neuropathic pain ... See more keywords

Role of homeostatic plasticity in critical brain dynamics following focal stroke lesions

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-80196-6

Abstract: Can focal brain lesions, such as those caused by stroke, disrupt critical brain dynamics? What biological mechanisms drive its recovery? In a recent study, we showed that focal lesions generate a sub-critical state that recovers… read more here.

Keywords: brain; brain dynamics; criticality; homeostatic plasticity ... See more keywords

Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2504775122

Abstract: Significance Homeostatic plasticity maintains normal brain functions by constraining various network features of neural circuits, yet how this is realized on the cellular level remains unknown. Synaptic and intrinsic forms of homeostatic plasticity adjust different… read more here.

Keywords: modular arrangement; plasticity; network; homeostatic plasticity ... See more keywords

Homeostatic Plasticity and External Input Shape Neural Network Dynamics

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recommendations! Published in 2018 at "Physical Review X"

DOI: 10.1103/physrevx.8.031018

Abstract: In vitro and in vivo spiking activity clearly differ. Whereas networks in vitro develop strong bursts separated by periods of very little spiking activity, in vivo cortical networks show continuous activity. This is puzzling considering… read more here.

Keywords: network; homeostatic plasticity; input; external input ... See more keywords

Putative roles for homeostatic plasticity in epileptogenesis

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recommendations! Published in 2023 at "Epilepsia"

DOI: 10.1111/epi.17500

Abstract: Homeostatic plasticity allows neural circuits to maintain an average activity level while preserving the ability to learn new associations and efficiently transmit information. This dynamic process usually protects the brain from excessive activity, like seizures.… read more here.

Keywords: homeostatic plasticity; plasticity epileptogenesis; plasticity; putative roles ... See more keywords

The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling

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recommendations! Published in 2018 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.aar4338

Abstract: Inactivation of the Fmr1 gene that is mutated in fragile X syndrome leads to loss of retinoic acid–mediated homeostatic plasticity in human neurons. A fragile neuronal network Inactivation of the fragile X mental retardation 1… read more here.

Keywords: human neurons; fmr1; homeostatic plasticity; retinoic acid ... See more keywords

Dynamic homeostatic plasticity within cerebellar circuitry

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731915

Abstract: The cerebellum has proved useful as a model system due to its uniform modular organization and explicit physiological significance of input and output signals. The cerebellum of the mormyrid fish provides a special opportunity to… read more here.

Keywords: cell; homeostatic plasticity; output; dynamic homeostatic ... See more keywords