Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole‐induced epilepsy through the induction of Homer1a
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14274
Abstract: Neuronal intrinsic homeostatic scaling‐down of excitatory synapse has been implicated in epilepsy pathogenesis to prevent the neuronal circuits from hyperexcitability. Recent findings suggest a role for neuronal PAS domain protein 4 (Npas4), an activity‐dependent neuron‐specific… read more here.
Keywords: pas domain; npas4; neuronal pas; npas4ko mice ... See more keywords
Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2017.00208
Abstract: Immediate early and constitutively expressed products of the Homer1 gene regulate the functional assembly of post-synaptic density proteins at glutamatergic synapses to influence excitatory neurotransmission and synaptic plasticity. Earlier studies of Homer1 gene knock-out (KO)… read more here.
Keywords: behavioral neurochemical; mice; cocaine; homer1 gene ... See more keywords