Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins
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DOI: 10.1093/gbe/evaa125
Abstract: Abstract Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface “self-associated molecular patterns” that modulate innate immunity via engagement… read more here.
Keywords: common ancestor; hominin siglec; biology; innate immunity ... See more keywords