Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2019.04.019
Abstract: l-Homoarginine (hArg) is biosynthesized from l-arginine (Arg) and l-lysine (Lys) by arginine:glycine amidinotransferase (AGAT). AGAT also catalyzes the formation of guanidinoacetate (GAA) from Arg and glycine (Gly). GAA is converted to creatine (N-methyl guanidinoacetate) by… read more here.
Keywords: evidence lysine; arginase; harg; homoarginine ... See more keywords
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22099-x
Abstract: The inhibition of arginase, resulting in higher arginine (ARG) availability for nitric oxide synthesis, may account for the putative protective effect of homoarginine (HOMOARG) against atherosclerosis and cardiovascular disease. However, uncertainty exists regarding the significance… read more here.
Keywords: arginase; homoarg; inhibition; homoarginine ... See more keywords
Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88986-y
Abstract: Endogenous arginine derivatives homoarginine, asymmetric dimethylarginine (ADMA) and symmetric dimethyarginine (SDMA) are independent mortality predictors in atherosclerotic cardiovascular disease (CVD). Our study reports the first analysis, whether homoarginine, ADMA and SDMA predict venous thromboembolism (VTE)… read more here.
Keywords: independently predict; mortality; homoarginine; venous thromboembolism ... See more keywords
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function
Sign Up to like & getrecommendations! Published in 2022 at "Circulation Research"
DOI: 10.1161/circresaha.122.321094
Abstract: Background: Amino acid metabolism is crucial for inflammatory processes during atherogenesis. The endogenous amino acid homoarginine is a robust biomarker for cardiovascular outcome and mortality with high levels being protective. However, the underlying mechanisms remain… read more here.
Keywords: cell; homoarginine supplementation; acid homoarginine; amino acid ... See more keywords
Influence of homoarginine on creatine accumulation and biosynthesis in the mouse
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.969702
Abstract: Organisms obtain creatine from their diet or by de novo synthesis via AGAT (L-arginine:glycine amidinotransferase) and GAMT (Guanidinoacetate N-methyltrasferase) in kidney and liver, respectively. AGAT also synthesizes homoarginine (hArg), low levels of which predict poor… read more here.
Keywords: supplementation; creatine; kidney; mouse ... See more keywords
Low-Circulating Homoarginine is Associated with Dilatation and Decreased Function of the Left Ventricle in the General Population
Sign Up to like & getrecommendations! Published in 2018 at "Biomolecules"
DOI: 10.3390/biom8030063
Abstract: Low homoarginine is an independent marker of mortality in heart failure patients and incident cardiovascular events. Whether homoarginine is related with healthier cardiac structure and function is currently unclear. We used data of the population-based… read more here.
Keywords: homoarginine associated; associated dilatation; homoarginine; function ... See more keywords