Homobivalent, Trivalent, and Covalent PROTACs: Emerging Strategies for Protein Degradation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00728
Abstract: Proteolysis-targeting chimeras (PROTACs) is a fast-growing technology providing many strengths over inhibition of protein activity directly and is attracting increasing interest in new drug discovery and development. However, efficiently identifying potent and drug-like degraders is… read more here.
Keywords: covalent protacs; protacs; protein degradation; trivalent ... See more keywords