A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105179
Abstract: Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the… read more here.
Keywords: protein protein; clinical translation; affinity; homodimerization ... See more keywords
Electrochemical impedance spectroscopy for quantization of matrix Metalloproteinase-14 based on peptides inhibiting its homodimerization and heterodimerization.
Sign Up to like & getrecommendations! Published in 2019 at "Talanta"
DOI: 10.1016/j.talanta.2019.120142
Abstract: We reported here two novel electrochemical impedance spectroscopy biosensors were developed for the first time for highly sensitive quantification of matrix metalloproteinase-14 (MMP-14) based on binding interaction between hemopexin-like domain (PEX) of MMP-14 (PEX-14) and… read more here.
Keywords: mmp; spectroscopy; impedance spectroscopy; homodimerization ... See more keywords
A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12081119
Abstract: Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity. Due to increasing numbers… read more here.
Keywords: setmelanotide like; homodimerization; mc4r; setmelanotide ... See more keywords
The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11030375
Abstract: Pertuzumab (Perjeta) is an anti-HER2 monoclonal antibody that is used for treatment of HER2-positive breast cancers in combination with trastuzumab (Herceptin) and docetaxel and showed promising clinical outcomes. Pertuzumab is suggested to block heterodimerization of… read more here.
Keywords: pertuzumab; her2 homodimerization; trastuzumab; her2 ... See more keywords
Experimental and Theoretical Study on the Homodimerization Mechanism of 3-Acetylcoumarin
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27217228
Abstract: In the present study, the reaction conditions for homodimerization process of 3-acetylcoumarin were achieved under sonication using combination of zinc and metallic salt (ZnCl2 or Zn(OAc)2). Appropriate frequency and sound amplitude have been identified as… read more here.
Keywords: experimental theoretical; reaction; homodimerization; mechanism ... See more keywords