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   Articles with "homodimerization" as a keyword



A Bionic‐Homodimerization Strategy for Optimizing Modulators of Protein–Protein Interactions: From Statistical Mechanics Theory to Potential Clinical Translation

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202105179

Abstract: Emerging protein–protein interaction (PPI) modulators have brought out exciting ability as therapeutics in human diseases, but its clinical translation has been greatly hampered by the limited affinity. Inspired by the homodimerize structure of antibody, the… read more here.

Keywords: protein protein; clinical translation; affinity; homodimerization ... See more keywords

Electrochemical impedance spectroscopy for quantization of matrix Metalloproteinase-14 based on peptides inhibiting its homodimerization and heterodimerization.

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recommendations! Published in 2019 at "Talanta"

DOI: 10.1016/j.talanta.2019.120142

Abstract: We reported here two novel electrochemical impedance spectroscopy biosensors were developed for the first time for highly sensitive quantification of matrix metalloproteinase-14 (MMP-14) based on binding interaction between hemopexin-like domain (PEX) of MMP-14 (PEX-14) and… read more here.

Keywords: mmp; spectroscopy; impedance spectroscopy; homodimerization ... See more keywords

Glycosylation Weakens Skp1 Homodimerization in Toxoplasma gondii by Interrupting a Fuzzy Interaction

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recommendations! Published in 2025 at "Biochemistry"

DOI: 10.1021/acs.biochem.4c00859

Abstract: Skp1/Cullin-1/F-Box protein (SCF) complexes represent a major class of E3 ubiquitin ligases responsible for proteomic control throughout eukaryotes. Target specificity is mediated by a large set of F-box proteins (FBPs) whose F-box domains interact with… read more here.

Keywords: toxoplasma gondii; interaction; skp1 homodimerization; homodimerization ... See more keywords

De novo discovery of a molecular glue–like macrocyclic peptide that induces MCL1 homodimerization

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2426006122

Abstract: Significance This study introduces a macrocyclic peptide that selectively targets myeloid cell leukemia 1 (MCL1), a critical antiapoptotic protein. Structural analysis reveals its unique function as a molecular glue, capable of inducing homodimerization of MCL1… read more here.

Keywords: homodimerization; molecular glue; novo discovery; discovery molecular ... See more keywords

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

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recommendations! Published in 2022 at "Biomolecules"

DOI: 10.3390/biom12081119

Abstract: Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity. Due to increasing numbers… read more here.

Keywords: setmelanotide like; homodimerization; mc4r; setmelanotide ... See more keywords

The Effects of Pertuzumab and Its Combination with Trastuzumab on HER2 Homodimerization and Phosphorylation

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recommendations! Published in 2019 at "Cancers"

DOI: 10.3390/cancers11030375

Abstract: Pertuzumab (Perjeta) is an anti-HER2 monoclonal antibody that is used for treatment of HER2-positive breast cancers in combination with trastuzumab (Herceptin) and docetaxel and showed promising clinical outcomes. Pertuzumab is suggested to block heterodimerization of… read more here.

Keywords: pertuzumab; her2 homodimerization; trastuzumab; her2 ... See more keywords

Experimental and Theoretical Study on the Homodimerization Mechanism of 3-Acetylcoumarin

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27217228

Abstract: In the present study, the reaction conditions for homodimerization process of 3-acetylcoumarin were achieved under sonication using combination of zinc and metallic salt (ZnCl2 or Zn(OAc)2). Appropriate frequency and sound amplitude have been identified as… read more here.

Keywords: experimental theoretical; reaction; homodimerization; mechanism ... See more keywords

Mitochondria-specific targeting of noncanonical EGR1 ntmRNA-coordinated mitophagy receptor BNIP3 homodimerization disrupts mitochondrial metabolism and suppresses hepatocellular carcinoma growth in vitro and in vivo.

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recommendations! Published in 2026 at "Theranostics"

DOI: 10.7150/thno.117745

Abstract: Background: Hypoxia-driven metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC) and depends critically on mitochondrial signaling. We sought to identify RNA-based molecular factors that orchestrate the hypoxia-mitochondria crosstalk and regulate metabolic adaptation in HCC… read more here.

Keywords: egr1 ntmrna; mitochondria specific; hepatocellular carcinoma; egr1 ... See more keywords