Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—A review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12152
Abstract: Ochronosis is the process in alkaptonuria (AKU) that causes all the debilitating morbidity. The process involves selective deposition of homogentisic acid (HGA)‐derived pigment in tissues altering the properties of these tissues, leading to their failure.… read more here.
Keywords: pigmentation caused; homogentisic acid; ochronotic pigmentation; disease ... See more keywords
HPLC with electrochemical detection for determining homogentisic acid and its application to urine from rats fed tyrosine-enriched food.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113253
Abstract: A highly sensitive method for determining urine homogentisic acid (HGA) is required to provide adequate diagnosis and therapy for alkaptonuria in early stages. In this study, we developed a highly sensitive high-performance liquid chromatography with… read more here.
Keywords: hga; hplc; homogentisic acid; hplc ecd ... See more keywords
Homogentisic acid-derived pigment as a biocompatible label for optoacoustic imaging of macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13041-4
Abstract: Macrophages are one of the most functionally-diverse cell types with roles in innate immunity, homeostasis and disease making them attractive targets for diagnostics and therapy. Photo- or optoacoustics could provide non-invasive, deep tissue imaging with… read more here.
Keywords: derived pigment; homogentisic acid; acid derived; macrophage ... See more keywords