Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
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DOI: 10.1093/nar/gkaa094
Abstract: Abstract During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by XRCC4:Ligase IV (X4L4). This physical juxtaposition of DNA ends is called NHEJ synapsis. In… read more here.
Keywords: homologous dna; end joining; synapsis; dna end ... See more keywords
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw877
Abstract: Homologous recombination (HR) is a template-driven repair pathway that mends DNA double-stranded breaks (DSBs), and thus helps to maintain genome stability. The RAD51 recombinase facilitates DNA joint formation during HR, but to accomplish this task,… read more here.
Keywords: homologous dna; isoform bccip; bccip; filament ... See more keywords