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   Articles with "homologous end" as a keyword



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Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process

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recommendations! Published in 2017 at "BioEssays"

DOI: 10.1002/bies.201600209

Abstract: Non‐homologous end‐joining (NHEJ) is the dominant means of repairing chromosomal DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins can be involved in the detection, signalling, synapsis, end‐processing and… read more here.

Keywords: end joining; end; homologous end; interaction ... See more keywords
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A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining

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recommendations! Published in 2017 at "Current Genetics"

DOI: 10.1007/s00294-017-0760-1

Abstract: Chromosomal breaks can be healed by several repair processes, including one called non-homologous end-joining (NHEJ) where the two broken ends are ligated together with a loss of 0–5 bp of DNA. The protein requirements for NHEJ… read more here.

Keywords: end joining; schizosaccharomyces pombe; homologous end; mrn ... See more keywords
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Deletion of yeast TPK1 reduces the efficiency of non-homologous end joining DNA repair.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.09.083

Abstract: Non-homologous end joining (NHEJ) is a highly conserved mechanism of DNA double-stranded break (DSB) repair. Here we utilize a computational protein-protein interaction method to identify human PRKACB as a potential candidate interacting with NHEJ proteins.… read more here.

Keywords: end joining; deletion; homologous end; tpk1 ... See more keywords

Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.

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recommendations! Published in 2018 at "DNA repair"

DOI: 10.1016/j.dnarep.2018.02.003

Abstract: When Fanconi Anemia (FA) proteins were depleted in human U2OS cells with integrated DNA repair reporters, we observed decreases in homologous recombination (HR), decreases in mutagenic non-homologous end joining (m-NHEJ) and increases in canonical NHEJ,… read more here.

Keywords: end joining; fanconi anemia; homologous end; replication associated ... See more keywords

MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.

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recommendations! Published in 2018 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.06.018

Abstract: The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with… read more here.

Keywords: end joining; dna damage; damage response; classical non ... See more keywords

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair.

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recommendations! Published in 2024 at "Oncogenesis"

DOI: 10.1038/s41389-023-00503-0

Abstract: Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone methyltransferase SMYD3 with the development and… read more here.

Keywords: progression; repair; endometrial cancer; non homologous ... See more keywords

Single-molecule imaging reveals the kinetics of non-homologous end-joining in living cells

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54545-y

Abstract: Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-stranded breaks (DSBs) in vertebrates. However, due to challenges in detecting DSBs in living cells, the repair capacity of the NHEJ pathway is unknown.… read more here.

Keywords: living cells; non homologous; homologous end; end joining ... See more keywords

Development of versatile non-homologous end joining-based knock-in module for genome editing

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-18911-9

Abstract: CRISPR/Cas9-based genome editing has dramatically accelerated genome engineering. An important aspect of genome engineering is efficient knock-in technology. For improved knock-in efficiency, the non-homologous end joining (NHEJ) repair pathway has been used over the homology-dependent… read more here.

Keywords: end joining; knock; genome editing; homologous end ... See more keywords

LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation

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recommendations! Published in 2018 at "Cell Cycle"

DOI: 10.1080/15384101.2018.1442625

Abstract: ABSTRACT LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet… read more here.

Keywords: end joining; cervical cancer; homologous end; nhej pathway ... See more keywords

Coevolution of Non-Homologous End Joining efficiency and encephalization.

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recommendations! Published in 2024 at "Journal of evolutionary biology"

DOI: 10.1093/jeb/voae057

Abstract: Double strand breaks, the most difficult to repair DNA damage, are mainly repaired by Non-Homologous End-Joining (NHEJ) or Homologous Recombination (HR). Previous studies seem to indicate that primates, and particularly humans, have a better NHEJ… read more here.

Keywords: efficiency; encephalization; non homologous; end joining ... See more keywords

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.

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recommendations! Published in 2021 at "Nucleic acids research"

DOI: 10.1093/nar/gkab871

Abstract: KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of multiple cancers, including colorectal cancer, but the underlying precise molecular mechanisms remain elusive. Herein we model the radiosensitivity of isogenic HCT116 and SW48 colorectal… read more here.

Keywords: end joining; nrf2 53bp1; radioresistance; homologous end ... See more keywords