Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600209
Abstract: Non‐homologous end‐joining (NHEJ) is the dominant means of repairing chromosomal DNA double strand breaks (DSBs), and is essential in human cells. Fifteen or more proteins can be involved in the detection, signalling, synapsis, end‐processing and… read more here.
Keywords: end joining; end; homologous end; interaction ... See more keywords
A curious new role for MRN in Schizosaccharomyces pombe non-homologous end-joining
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DOI: 10.1007/s00294-017-0760-1
Abstract: Chromosomal breaks can be healed by several repair processes, including one called non-homologous end-joining (NHEJ) where the two broken ends are ligated together with a loss of 0–5 bp of DNA. The protein requirements for NHEJ… read more here.
Keywords: end joining; schizosaccharomyces pombe; homologous end; mrn ... See more keywords
Deletion of yeast TPK1 reduces the efficiency of non-homologous end joining DNA repair.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.09.083
Abstract: Non-homologous end joining (NHEJ) is a highly conserved mechanism of DNA double-stranded break (DSB) repair. Here we utilize a computational protein-protein interaction method to identify human PRKACB as a potential candidate interacting with NHEJ proteins.… read more here.
Keywords: end joining; deletion; homologous end; tpk1 ... See more keywords
Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.02.003
Abstract: When Fanconi Anemia (FA) proteins were depleted in human U2OS cells with integrated DNA repair reporters, we observed decreases in homologous recombination (HR), decreases in mutagenic non-homologous end joining (m-NHEJ) and increases in canonical NHEJ,… read more here.
Keywords: end joining; fanconi anemia; homologous end; replication associated ... See more keywords
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.06.018
Abstract: The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with… read more here.
Keywords: end joining; dna damage; damage response; classical non ... See more keywords
Development of versatile non-homologous end joining-based knock-in module for genome editing
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-18911-9
Abstract: CRISPR/Cas9-based genome editing has dramatically accelerated genome engineering. An important aspect of genome engineering is efficient knock-in technology. For improved knock-in efficiency, the non-homologous end joining (NHEJ) repair pathway has been used over the homology-dependent… read more here.
Keywords: end joining; knock; genome editing; homologous end ... See more keywords
LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2018.1442625
Abstract: ABSTRACT LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet… read more here.
Keywords: end joining; cervical cancer; homologous end; nhej pathway ... See more keywords
Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab871
Abstract: KRAS-activating mutations are oncogenic drivers and are correlated with radioresistance of multiple cancers, including colorectal cancer, but the underlying precise molecular mechanisms remain elusive. Herein we model the radiosensitivity of isogenic HCT116 and SW48 colorectal… read more here.
Keywords: end joining; nrf2 53bp1; radioresistance; homologous end ... See more keywords
H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx715
Abstract: Abstract Phosphorylated histone H2AX, termed ‘γH2AX’, mediates the chromatin response to DNA double strand breaks (DSBs) in mammalian cells. H2AX deficiency increases the numbers of unrepaired DSBs and translocations, which are partly associated with defects… read more here.
Keywords: end joining; h2ax; homologous end; non homologous ... See more keywords
Abstract 2827: Alternative non-homologous end joining DNA repair as therapeutic target in multiple myeloma
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DOI: 10.1158/1538-7445.am2018-2827
Abstract: Citation Format: Daniele Caracciolo, Martina Montesano, Emanuela Altomare, Grazia Consolo, Nicola Amodio, Maria Teresa Di Martino, Marco Rossi, Cirino Botta, Eugenio Morelli, Giada Juli, Pierosandro Tagliaferri, Pierfrancesco Tassone. Alternative non-homologous end joining DNA repair as… read more here.
Keywords: end joining; dna repair; alternative non; homologous end ... See more keywords
PHF6 promotes non‐homologous end joining and G2 checkpoint recovery
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DOI: 10.15252/embr.201948460
Abstract: The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library… read more here.
Keywords: end joining; recovery; dna; homologous end ... See more keywords