Homologous repair deficiencies and current insights in clinical evaluation of PARP inhibitors in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-020-00599-9
Abstract: Homologous repair deficiency is a clinically relevant molecular aberration in prostate cancer. The goal of this short review is to summarize the study landscape of treatments targeting these aberrations through discussion of the most relevant clinical… read more here.
Keywords: parp inhibitors; prostate cancer; cancer; homologous repair ... See more keywords
Abstract PR06: Targeted chemotherapy for Homologous Repair Defects (HRD) in molecularly profiled cancer patients
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.dnarepair16-pr06
Abstract: Precision Medicine Tumor Boards (PMTB) are now established at many academic institutions and provide a forum for multidisciplinary teams to discuss tumor profiling results to aid treatment choices for cancer patients. PMTBs typically focus on… read more here.
Keywords: molecularly profiled; cancer; cancer patients; homologous repair ... See more keywords
Functional biomarkers of homologous repair (HR) deficiency to guide novel DNA damage response targeted therapy in clear cell renal cell carcinoma (ccRCC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4576
Abstract: 4576Background: Treatment for advanced ccRCC has rapidly evolved; however, responses are not uniform and synthetic lethal treatments with associated predictive biomarkers are still lacking. We prev... read more here.
Keywords: homologous repair; repair deficiency; biomarkers homologous; functional biomarkers ... See more keywords
Homologous repair deficiency in VHL-mutated clear cell renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.6_suppl.585
Abstract: 585Background: Clear cell renal cell carcinoma (ccRCC) displays genomic instability across all tumor stages, indicative of increased replicative stress and defects in DNA damage response (DDR) pathways including homologous repair (HR); however ccRCC does not… read more here.
Keywords: cell renal; renal cell; homologous repair; cell carcinoma ... See more keywords