Generation of human induced pluripotent stem cell lines carrying homozygous JAG1 deletions.
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DOI: 10.1016/j.scr.2021.102588
Abstract: JAG1gene encodes Jagged1 protein, which is a ligand for NOTCH receptors. JAG1 mutations cause Alagille syndrome, in which liver failure occurs caused by abnormalities in the bile ducts. In this study, we generated two homozygous… read more here.
Keywords: homozygous jag1; stem cell; ipsc lines; human ... See more keywords