Apoptotic and antihepatofibrotic effect of honokiol via activation of GSK3β and suppression of Wnt/β‐catenin pathway in hepatic stellate cells
Sign Up to like & getrecommendations! Published in 2020 at "Phytotherapy Research"
DOI: 10.1002/ptr.6824
Abstract: Though honokiol, derived from the Magnolia tree, was known to suppress renal fibrosis, pulmonary fibrosis, non‐alcoholic steatoheptitis, inflammation and cancers, the underlying antifibrotic mechanisms of honokiol are not fully understood in hepatic stellate cells until… read more here.
Keywords: catenin; hepatic stellate; honokiol; gsk3 ... See more keywords
Honokiol antagonizes doxorubicin resistance in human breast cancer via miR-188-5p/FBXW7/c-Myc pathway
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-021-04238-w
Abstract: Honokiol, a natural phenolic compound derived from Magnolia plants, is a promising anti-tumor compound that exerts a wide range of anti-cancer effects. Herein, we investigated the effect of honokiol on doxorubicin resistance in breast cancer.… read more here.
Keywords: breast cancer; honokiol; cancer; fbxw7 ... See more keywords
Antiparasitic efficacy of honokiol against Cryptocaryon irritans in pompano, Trachinotus ovatus
Sign Up to like & getrecommendations! Published in 2019 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.10.037
Abstract: Abstract Cryptocaryon irritans, a marine fish ectoparasite, causes mass economic loss in the mariculture and ornamental fish industries. It is important to find effective alternatives that may be both affordable and environmentally acceptable to control… read more here.
Keywords: trachinotus ovatus; honokiol; cryptocaryon irritans; irritans theronts ... See more keywords
The effect of honokiol on pulmonary artery endothelium cell autophagy mediated by cyclophilin A in hypoxic pulmonary arterial hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2019.01.005
Abstract: Abnormal autophagy plays critical roles in the structure and function of the pulmonary vasculature. Cyclophilin A (CyPA) can be secreted from cells in response to hypoxia and oxidative stress, which are involved in inducing autophagy… read more here.
Keywords: arterial hypertension; pulmonary arterial; honokiol; autophagy ... See more keywords
High Value-Added Application of Natural Plant Products in Crop Protection: Honokiol Monoester/Diester Derivatives Containing the Novel Core Scaffold of Benzodihydrofuran and Their Agricultural Bioactivities and Control Effects.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c08292
Abstract: To discover new potential botanical insecticides from plant secondary metabolites, a series of new honokiol-type monoester/diester derivatives containing the core scaffold of benzodihydrofuran were synthesized by structural modification of honokiol. Against Mythimna separata Walker, 2-hydroxymethy-5-(2'-(para-chlorobenzoyloxy)-5'-(1″,2″-epoxypropanyl))phenyl-2,3-dihydrobenzofuran… read more here.
Keywords: epoxypropanyl phenyl; diester derivatives; honokiol; phenyl dihydrobenzofuran ... See more keywords
Honokiol Inhibits the Inflammatory Response and Lipid Metabolism Disorder by Inhibiting p38 α in Alcoholic Liver Disease
Sign Up to like & getrecommendations! Published in 2022 at "Planta Medica"
DOI: 10.1055/a-1878-3991
Abstract: Abstract Alcoholic liver disease is one of the leading causes of liver-related morbidity and mortality worldwide, but effective treatments are still lacking. Honokiol, a lignin-type natural compound isolated from the leaves and bark of Magnolia… read more here.
Keywords: alcoholic liver; lipid metabolism; expression; honokiol ... See more keywords
Use of honokiol in lung cancer therapy: a mini review of its pharmacological mechanism.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2193695
Abstract: Honokiol (3',5-di-(2-propenyl)-1,1'-biphenyl-2,2'-diol) is a biologically active natural product derived from Magnolia and has been shown to have excellent biological activities. This paper discusses research progress on the use of honokiol in the treatment of lung… read more here.
Keywords: lung cancer; use honokiol; honokiol;
Extraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2071887
Abstract: Abstract Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds from four traditional Chinese medicine extracts and evaluated their… read more here.
Keywords: vitro vivo; medicine; artemisia argyi; honokiol ... See more keywords
Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15837
Abstract: Mitochondrial damage and oxidative stress are crucial contributors to the tubular cell injury and death in acute kidney injury. Novel therapeutic strategies targeting mitochondria protection and halting the progression of acute kidney injury are urgently… read more here.
Keywords: acute kidney; kidney injury; honokiol; cisplatin induced ... See more keywords
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13474
Abstract: Honokiol, an active natural product derived from Magnolia officinalis, exerted anticancer effects through a variety of mechanisms on multiple types of cancers. In this study, the molecular mechanisms of honokiol in suppressing the human oral… read more here.
Keywords: oral squamous; cell cycle; honokiol; autophagy ... See more keywords
Honokiol Inhibits SARS-CoV-2 Replication in Cell Culture at a Post-Entry Step
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03273-22
Abstract: Honokiol is a compound that shows both anti-inflammatory and antiviral effects, and therefore its effect on SARS-CoV-2 infection was assessed. This small molecule inhibited SARS-CoV-2 replication in various cell-based infection systems, with up to an… read more here.
Keywords: effect; replication; infection; cov replication ... See more keywords