From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement.
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DOI: 10.1021/acs.jmedchem.0c01265
Abstract: The tyrosine phosphatase SHP2 controls the activity of pivotal signaling pathways, including MAPK, JAK-STAT, and PI3K-Akt. Aberrant SHP2 activity leads to uncontrolled cell proliferation, tumorigenesis, and metastasis. SHP2 signaling was recently linked to drug resistance… read more here.
Keywords: shp2; shp2 inhibitors; scaffold hopping; hopping bioisosteric ... See more keywords