Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex
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DOI: 10.1038/s41467-025-61176-4
Abstract: Molecular glues, small molecules that bind cooperatively at a protein-protein interface, have emerged as powerful modalities for the modulation of protein-protein interactions (PPIs) and “undruggable” targets. The systematic identification of new chemical matter with a… read more here.
Keywords: chemistry; molecular glues; scaffold hopping; hopping molecular ... See more keywords