The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-05834-1
Abstract: Autophagy, the process of elimination of cellular components by lysosomal degradation, is essential for animal development and homeostasis. Using the autophagy-dependent Drosophila larval midgut degradation model we identified an autophagy regulator, the RING domain ubiquitin… read more here.
Keywords: znrf1 homologue; homologue detour; hops complex; detour ... See more keywords
The HOPS complex subunit VPS39 controls ciliogenesis through autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddaa029
Abstract: Abstract Primary cilia are microtubule-based organelles that assemble and protrude from the surface of most mammalian cells during quiescence. The biomedical relevance of cilia is indicated by disorders ascribed to cilia dysfunction, known as ciliopathies,… read more here.
Keywords: hops complex; ciliogenesis; vps39 controls; ciliogenesis autophagy ... See more keywords