Oxidative stress in adult growth hormone deficiency: different plasma antioxidant patterns in comparison with metabolic syndrome
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DOI: 10.1007/s12020-017-1468-1
Abstract: Background and aimsGrowth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in… read more here.
Keywords: plasma; plasma antioxidant; metabolic syndrome; hormone deficiency ... See more keywords
Treatment of adult growth hormone deficiency with human recombinant growth hormone: an update on current evidence and critical review of advantages and pitfalls
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DOI: 10.1007/s12020-017-1492-1
Abstract: Adult-onset growth-hormone (GH) deficiency (GHD) is a rare disorder, which most commonly results from pituitary or peripituitary tumors and their treatment, and is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral… read more here.
Keywords: treatment; evidence; growth hormone; hormone deficiency ... See more keywords
Growth hormone deficiency in children: From suspecting to diagnosing
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DOI: 10.1007/s13312-017-1190-3
Abstract: Isolated Growth hormone deficiency is an important and treatable cause of short stature. However, it is often difficult to diagnose the condition with certainty due to the lack of a single robust diagnostic test. Short… read more here.
Keywords: growth hormone; growth; hormone deficiency; deficiency children ... See more keywords
Safety and effectiveness of Omnitrope® in patients with growth hormone deficiency: snapshot analysis of PATRO Adults study in the Italian population
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DOI: 10.1007/s40618-020-01308-3
Abstract: Purpose PATRO adults is an ongoing, multicenter, observational, post-marketing surveillance study aimed at investigating the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the recombinant human growth hormone (rhGH) Omnitrope® during routine clinical practice.… read more here.
Keywords: patro adults; safety; growth hormone; snapshot analysis ... See more keywords
Targeting GH-1 splicing as a novel pharmacological strategy for growth hormone deficiency type II.
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DOI: 10.1016/j.bcp.2016.07.016
Abstract: Isolated growth hormone deficiency type II (IGHD II) is a rare genetic splicing disorder characterized by reduced growth hormone (GH) secretion and short stature. It is mainly caused by autosomal dominant-negative mutations within the growth… read more here.
Keywords: growth hormone; growth; hormone deficiency; deficiency type ... See more keywords
Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency
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DOI: 10.1038/gim.2017.165
Abstract: PurposeCombined pituitary hormone deficiency (CPHD) is characterized by a malformed or underdeveloped pituitary gland resulting in an impaired pituitary hormone secretion. Several transcription factors have been described in its etiology, but defects in known genes… read more here.
Keywords: slc20a1 slc15a4; pituitary hormone; hormone deficiency;
Prevalence of growth hormone deficiency in middle-age adults recovering from stroke
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DOI: 10.1080/02699052.2019.1682195
Abstract: ABSTRACT Objective: The prevalence of chronic growth hormone deficiency (GHD) and its association with other hormonal deficiencies was determined in middle-aged patients post-stroke with and without consideration of body mass index (BMI). Methods: Clinical records… read more here.
Keywords: ghd; growth hormone; hormone deficiency; prevalence ... See more keywords
Is growth hormone administration essential for in vitro fertilization treatment of female patients with growth hormone deficiency?
Sign Up to like & getrecommendations! Published in 2019 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2018.1492044
Abstract: ABSTRACT Available evidence suggests that the fertility of growth hormone deficient female patients could be decreased, although the responsible mechanisms are unknown. Taking into account the multiple effects of growth hormone on reproduction suggested by… read more here.
Keywords: treatment; growth hormone; growth; hormone deficiency ... See more keywords
Gitelman syndrome combined with growth hormone deficiency
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DOI: 10.1097/md.0000000000017244
Abstract: Abstract Rationale: Gitelman syndrome (GS) is a rare autosomal recessive hereditary salt-losing tubulopathy caused by loss-of-function mutations in the SLC12A3 gene. It is usually characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. There are only… read more here.
Keywords: gitelman syndrome; growth; hormone deficiency; growth hormone ... See more keywords
Molecular analysis of brazilian patients with combined pituitary hormone deficiency and orthotopic posterior pituitary lobe reveals eight different PROP1 alterations with three novel mutations
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DOI: 10.1111/cen.13430
Abstract: Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). read more here.
Keywords: orthotopic posterior; posterior pituitary; pituitary hormone; pituitary lobe ... See more keywords
Novel GLI2 mutations identified in patients with Combined Pituitary Hormone Deficiency (CPHD): Evidence for a pathogenic effect by functional characterization
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Endocrinology"
DOI: 10.1111/cen.13914
Abstract: The Gli‐family of zinc‐finger transcription factors regulates the Sonic Hedgehog (Shh) signalling pathway that plays a key role in early pituitary and ventral forebrain development. Heterozygous GLI2 loss of function mutations in humans have been… read more here.
Keywords: combined pituitary; hormone deficiency; pituitary hormone; gli2 ... See more keywords