Thyroid Hormone Deficiency Disrupts Embryonic Ventral Body Wall Development and Myogenesis With Partial Recovery Following LevothyroxineTherapy
Sign Up to like & getrecommendations! Published in 2025 at "Birth Defects Research"
DOI: 10.1002/bdr2.2520
Abstract: Ventral body wall defects (VBWDs), including omphalocele and gastroschisis, result from failed embryonic midline closure and contribute to high neonatal morbidity. While thyroid hormones (THs) are essential for morphogenesis, their role in VBWD pathogenesis is… read more here.
Keywords: body wall; hormone deficiency; thyroid hormone; ventral body ... See more keywords
Unveiling the metabolomic profile of growth hormone deficiency children using NMR spectroscopy
Sign Up to like & getrecommendations! Published in 2025 at "Metabolomics"
DOI: 10.1007/s11306-024-02217-9
Abstract: The diagnosis of Growth Hormone Deficiency (GHD) during childhood has been the subject of much controversy over the last few years. Aiming to accurate medical treatment, there is a need for biomarker discovery. To characterize… read more here.
Keywords: spectroscopy; growth hormone; hormone deficiency;
Oxidative stress in adult growth hormone deficiency: different plasma antioxidant patterns in comparison with metabolic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1468-1
Abstract: Background and aimsGrowth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in… read more here.
Keywords: plasma; plasma antioxidant; metabolic syndrome; hormone deficiency ... See more keywords
Treatment of adult growth hormone deficiency with human recombinant growth hormone: an update on current evidence and critical review of advantages and pitfalls
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1492-1
Abstract: Adult-onset growth-hormone (GH) deficiency (GHD) is a rare disorder, which most commonly results from pituitary or peripituitary tumors and their treatment, and is characterized by alterations in body composition, carbohydrate and lipid metabolism, bone mineral… read more here.
Keywords: treatment; evidence; growth hormone; hormone deficiency ... See more keywords
Growth hormone deficiency in children: From suspecting to diagnosing
Sign Up to like & getrecommendations! Published in 2017 at "Indian Pediatrics"
DOI: 10.1007/s13312-017-1190-3
Abstract: Isolated Growth hormone deficiency is an important and treatable cause of short stature. However, it is often difficult to diagnose the condition with certainty due to the lack of a single robust diagnostic test. Short… read more here.
Keywords: growth hormone; growth; hormone deficiency; deficiency children ... See more keywords
Safety and effectiveness of Omnitrope® in patients with growth hormone deficiency: snapshot analysis of PATRO Adults study in the Italian population
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01308-3
Abstract: Purpose PATRO adults is an ongoing, multicenter, observational, post-marketing surveillance study aimed at investigating the long-term safety (primary endpoint) and effectiveness (secondary endpoint) of the recombinant human growth hormone (rhGH) Omnitrope® during routine clinical practice.… read more here.
Keywords: patro adults; safety; growth hormone; snapshot analysis ... See more keywords
Targeting GH-1 splicing as a novel pharmacological strategy for growth hormone deficiency type II.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2016.07.016
Abstract: Isolated growth hormone deficiency type II (IGHD II) is a rare genetic splicing disorder characterized by reduced growth hormone (GH) secretion and short stature. It is mainly caused by autosomal dominant-negative mutations within the growth… read more here.
Keywords: growth hormone; growth; hormone deficiency; deficiency type ... See more keywords
Identification of SLC20A1 and SLC15A4 among other genes as potential risk factors for combined pituitary hormone deficiency
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/gim.2017.165
Abstract: PurposeCombined pituitary hormone deficiency (CPHD) is characterized by a malformed or underdeveloped pituitary gland resulting in an impaired pituitary hormone secretion. Several transcription factors have been described in its etiology, but defects in known genes… read more here.
Keywords: slc20a1 slc15a4; pituitary hormone; hormone deficiency;
Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
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DOI: 10.1038/s41467-024-49996-2
Abstract: Mammalian hibernators survive prolonged periods of cold and resource scarcity by temporarily modulating normal physiological functions, but the mechanisms underlying these adaptations are poorly understood. The hibernation cycle of thirteen-lined ground squirrels (Ictidomys tridecemlineatus) lasts… read more here.
Keywords: hibernation; ground; hormone deficiency; ground squirrels ... See more keywords
Prevalence of growth hormone deficiency in middle-age adults recovering from stroke
Sign Up to like & getrecommendations! Published in 2019 at "Brain Injury"
DOI: 10.1080/02699052.2019.1682195
Abstract: ABSTRACT Objective: The prevalence of chronic growth hormone deficiency (GHD) and its association with other hormonal deficiencies was determined in middle-aged patients post-stroke with and without consideration of body mass index (BMI). Methods: Clinical records… read more here.
Keywords: ghd; growth hormone; hormone deficiency; prevalence ... See more keywords
Is growth hormone administration essential for in vitro fertilization treatment of female patients with growth hormone deficiency?
Sign Up to like & getrecommendations! Published in 2019 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2018.1492044
Abstract: ABSTRACT Available evidence suggests that the fertility of growth hormone deficient female patients could be decreased, although the responsible mechanisms are unknown. Taking into account the multiple effects of growth hormone on reproduction suggested by… read more here.
Keywords: treatment; growth hormone; growth; hormone deficiency ... See more keywords