Nuclear hormone receptors promote gut and glia detoxifying enzyme induction and protect C. elegans from the mold P. brevicompactum
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110166
Abstract: SUMMARY Animals encounter microorganisms in their habitats, adapting physiology and behavior accordingly. The nematode Caenorhabditis elegans is found in microbe-rich environments; however, its responses to fungi are not extensively studied. Here, we describe interactions of… read more here.
Keywords: brevicompactum; induction; hormone receptors; nuclear hormone ... See more keywords
Thyroid Hormone Disruption by Organophosphate Esters Is Mediated by Nuclear/Membrane Thyroid Hormone Receptors: In Vitro, In Vivo, and In Silico Studies.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c05956
Abstract: Earlier mechanistic studies of many prohibited flame retardants (FRs) highlighted their thyroid hormone-disrupting activity through nuclear thyroid hormone receptors (nTRs), whereas some alternative FRs such as organophosphate esters (OPEs) exerted weak nTR-disrupting effects. However, an… read more here.
Keywords: hormone; organophosphate esters; hormone receptors; thyroid hormone ... See more keywords
Abstract IA30: Targeting hormone receptors for degradation: Nuclear receptor downregulation as a therapeutic approach in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1557-3265.pmccavuln16-ia30
Abstract: Durable clinical responses to endocrine therapies in breast cancer are limited by the development of resistance that can occur as a consequence of estrogen receptor–alpha (ERα) mutations, the production of non-canonical ER ligands, or to… read more here.
Keywords: receptors degradation; downregulation; hormone receptors; cancer ... See more keywords
Immunohistochemistry defined subtypes of breast cancer in 678 Sudanese and Eritrean women; hospitals based case series
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3805-4
Abstract: BackgroundBreast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast cancer prevalence and mortality are steadily increasing. Knowledge of hormone receptors and human epidermal growth factor receptor-2… read more here.
Keywords: age; case; breast cancer; hormone receptors ... See more keywords
Expression of hypothalamic-pituitary-gonadal axis-related hormone receptors in low-grade serous ovarian cancer (LGSC)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-016-0300-5
Abstract: BackgroundThe aim of our study was to investigate the clinical features and expression levels of hypothalamic-pituitary-gonadal axis-related hormone receptors in low-grade serous ovarian cancer (LGSC).MethodsWe retrospectively investigated the clinical features of 26 consecutive patients with… read more here.
Keywords: hormone; pituitary gonadal; hypothalamic pituitary; gonadal axis ... See more keywords
Drug-induced diabetes type 2: In silico study involving class B GPCRs
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0208892
Abstract: A disturbance of glucose homeostasis leading to type 2 diabetes mellitus (T2DM) is one of the severe side effects that may occur during a prolonged use of many drugs currently available on the market. In… read more here.
Keywords: hormone; study; drug induced; hormone receptors ... See more keywords
Editorial: Steroid hormone receptors and cell cycle in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1196523
Abstract: COPYRIGHT © 2023 Fabris, Spring and Helguero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided… read more here.
Keywords: receptors cell; cell cycle; editorial steroid; hormone receptors ... See more keywords
Differential expression of nuclear hormone receptors by dendritic cell subsets in human vaginal mucosa and skin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1063343
Abstract: Nuclear hormone receptors (NHRs) expressed by dendritic cells (DCs), the major immune inducers and regulators, could play important roles in host immunity. Assessment of NHRs expressed by DCs in the vaginal mucosa (VM), in comparison… read more here.
Keywords: cell; expression; hormone receptors; nuclear hormone ... See more keywords
Differential Expression of Steroid Hormone Receptors and Ten Eleven Translocation Proteins in Endometrial Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.763464
Abstract: Steroid hormones govern the complex, cyclic changes of the endometrium, predominantly through their receptors. An interplay between steroid hormones and epigenetic mechanisms controls the dynamic endometrial gene regulation. Abnormalities in expression of genes and enzymes… read more here.
Keywords: endometrial cancer; expression; hormone receptors; steroid hormone ... See more keywords
Case report: Response to endocrine therapy in triple-negative breast cancer metastases with altered hormone receptors
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1023787
Abstract: Triple-negative breast cancer refers to breast cancer patients with negative estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Metastatic triple-negative breast cancer is predominantly treated with chemotherapy, but later-line treatment… read more here.
Keywords: triple negative; hormone receptors; breast cancer; negative breast ... See more keywords
Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19020542
Abstract: Adipokinetic hormone (AKH) is a highly researched insect neuropeptide that induces the mobilization of carbohydrates and lipids from the fat body at times of high physical activity, such as flight and locomotion. As a naturally… read more here.
Keywords: hormone; akh; adipokinetic hormone; hormone receptors ... See more keywords