Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone‐releasing hormone
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22879
Abstract: Growth hormone‐releasing hormone (GHRH) is a hypothalamic hormone, which regulates the secretion of growth hormone (GH) from the anterior pituitary gland. The effects of GHRH extend beyond the GH—insulin‐like growth factor I axis, and that… read more here.
Keywords: hormone; releasing hormone; hormone releasing; growth hormone ... See more keywords
Structural basis for activation of the growth hormone-releasing hormone receptor
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18945-0
Abstract: Growth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its binding to the cognate receptor (GHRHR). Malfunction in GHRHR signaling is associated with abnormal… read more here.
Keywords: hormone; releasing hormone; hormone releasing; growth hormone ... See more keywords
Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216814120
Abstract: Spinal muscular atrophy (SMA) is a severe autosomal recessive neuromuscular disease affecting children and young adults, caused by mutations of the survival motor neuron 1 gene (SMN1). SMA is characterized by the degeneration of spinal… read more here.
Keywords: spinal muscular; hormone; muscular atrophy; growth hormone ... See more keywords
Physiological and metabolic characteristics of novel double‐mutant female mice with targeted disruption of both growth hormone‐releasing hormone and growth hormone receptor
Sign Up to like & getrecommendations! Published in 2021 at "Aging Cell"
DOI: 10.1111/acel.13339
Abstract: Mice with disruptions of growth hormone‐releasing hormone (GHRH) or growth hormone receptor (GHR) exhibit similar phenotypes of prolonged lifespan and delayed age‐related diseases. However, these two models respond differently to calorie restriction indicating that they… read more here.
Keywords: hormone; hormone releasing; growth hormone; female mice ... See more keywords
Regulation of Vascular Calcification by Growth Hormone–Releasing Hormone and Its Agonists
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.117.312418
Abstract: Rationale: Vascular calcification (VC) is a marker of the severity of atherosclerotic disease. Hormones play important roles in regulating calcification; estrogen and parathyroid hormones exert opposing effects, the former alleviating VC and the latter exacerbating… read more here.
Keywords: hormone; vascular calcification; hormone releasing; calcification ... See more keywords
Effects of an Antagonistic Analog of Growth Hormone-Releasing Hormone on Endometriosis in a Mouse Model and In Vitro
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive Sciences"
DOI: 10.1177/1933719117691140
Abstract: Endometriosis is a benign gynecologic disorder causing dysmenorrhea, pelvic pain, and subfertility. Receptors for the growth hormone-releasing hormone (GHRH) were found in endometriotic tissues. Antagonists of GHRH have been used to inhibit the growth of… read more here.
Keywords: endometriosis; hormone; hormone releasing; mia 602 ... See more keywords
Perceptions and Knowledge of Women Regarding Contraception and Current Trends in Contraceptive Use in Korea
Sign Up to like & getrecommendations! Published in 2022 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2022.0133
Abstract: Purpose This study aimed to investigate the perceptions and behaviors of Korean women of reproductive age in regards to contraception counseling. Materials and Methods The study sample was collected in Korea and comprised 1011 women… read more here.
Keywords: women used; contraception; subdermal implants; hormone releasing ... See more keywords
Antagonist of Growth Hormone-Releasing Hormone Potentiates the Antitumor Effect of Pemetrexed and Cisplatin in Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911248
Abstract: Pleural mesothelioma (PM) is an aggressive cancer with poor prognosis and no effective therapies, mainly caused by exposure to asbestos. Antagonists of growth hormone-releasing hormone (GHRH) display strong antitumor effects in many experimental cancers, including… read more here.
Keywords: hormone; growth; growth hormone; pleural mesothelioma ... See more keywords
Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variants in Primary Human Endometrial Carcinomas: Novel Therapeutic Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27092671
Abstract: Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of various tumors, including endometrial carcinomas (EC). However, tumoral receptors that mediate the antiproliferative effects of GHRH antagonists in human ECs have not been fully characterized.… read more here.
Keywords: releasing hormone; hormone; ghrh; growth hormone ... See more keywords
Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.336135
Abstract: Both inflammation and anti-inflammation are involved in the protection of retinal cells. Antagonists of the hypothalamic growth hormone-releasing hormone receptor (GHRHR) have been shown to possess potent anti-inflammatory properties in experimental disease models of various… read more here.
Keywords: releasing hormone; hormone; hormone receptor; growth hormone ... See more keywords