Treatment Patterns and Survival Among Veterans With De Novo Metastatic Hormone-Sensitive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2025 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2025.9433
Abstract: Key Points Question How has treatment for and survival of metastatic hormone-sensitive prostate cancer (mHSPC) changed over time? Findings In a cross-sectional study of 6216 veterans with de novo mHSPC, the use of combination therapy… read more here.
Keywords: veterans novo; sensitive prostate; metastatic hormone; prostate cancer ... See more keywords
Increased MYBL2 expression in aggressive hormone‐sensitive prostate cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13314
Abstract: Loss of the histone demethylase KDM5D (lysine‐specific demethylase 5D) leads to in vitro resistance of prostate cancer cells to androgen deprivation therapy (ADT) with and without docetaxel. We aimed to define downstream drivers of the KDM5D… read more here.
Keywords: prostate cancer; prostate; expression; hormone sensitive ... See more keywords
Controversies in metastatic hormone‐sensitive prostate cancer
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DOI: 10.1002/cncr.70030
Abstract: Metastatic hormone‐sensitive prostate cancer (mHSPC) is an incurable phase of prostate cancer. Diagnostic tools and management strategies for this complex disease are expanding. Despite these advances, more therapies may not be the optimal approach for… read more here.
Keywords: cancer; prostate; sensitive prostate; metastatic hormone ... See more keywords
A Missense Variant Arg611Cys in LIPE which Encodes Hormone Sensitive Lipase Decreases Lipolysis and Increases Risk of Type 2 Diabetes in American Indians.
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes/metabolism research and reviews"
DOI: 10.1002/dmrr.3504
Abstract: AIMS Hormone sensitive lipase (HSL), encoded by the LIPE gene, is involved in lipolysis. Based on prior animal and human studies, LIPE was analyzed as a candidate gene for the development of type 2 diabetes… read more here.
Keywords: cys allele; american indians; hormone sensitive; lipolysis ... See more keywords
Risk classification by pathological and biochemical prognostic factors determined by extensive exploration for metastatic hormone sensitive prostate cancer
Sign Up to like & getrecommendations! Published in 2025 at "World Journal of Urology"
DOI: 10.1007/s00345-025-05862-4
Abstract: To determine prognostic parameters, we extensively examined whether physical, biochemical, and histological factors were associated with clinical outcomes in metastatic hormone sensitive prostate cancer (mHSPC) patients. A total 822 mHSPC patients were retrospectively investigated and… read more here.
Keywords: classification; risk classification; metastatic hormone; risk ... See more keywords
Is There a Benefit of Addition Docetaxel, Abiraterone, Celecoxib, or Zoledronic Acid in Initial Treatments for Patients Older Than 70 Years With Hormone-sensitive Advanced Prostate Cancer? A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical genitourinary cancer"
DOI: 10.1016/j.clgc.2019.05.001
Abstract: BACKGROUND Results from large randomized controlled trials combining docetaxel, abiraterone, celecoxib, or bisphosphonates with androgen deprivation therapy (ADT) in hormone-sensitive prostate cancer have emerged. However, in our knowledge, few data are available in patients older… read more here.
Keywords: docetaxel abiraterone; hormone sensitive; cancer; addition ... See more keywords
Survival benefit, disease progression and quality-of-life outcomes of abiraterone acetate plus prednisone versus docetaxel in metastatic hormone-sensitive prostate cancer: A network meta-analysis.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of cancer"
DOI: 10.1016/j.ejca.2018.08.010
Abstract: AIM Androgen deprivation therapy (ADT) has long been the gold standard for patients with metastatic hormone-sensitive prostate cancer (mHSPC). Clinical trials have demonstrated significant survival benefits when docetaxel (DOC) or abiraterone acetate (AA) and prednisone… read more here.
Keywords: prostate; hormone sensitive; metastatic hormone; sensitive prostate ... See more keywords
A Cost-effectiveness Analysis of Systemic Therapy for Metastatic Hormone-sensitive Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European urology oncology"
DOI: 10.1016/j.euo.2019.01.004
Abstract: BACKGROUND Following the recent publication of results from randomized trials that have demonstrated a survival benefit for the addition of docetaxel or abiraterone acetate to androgen deprivation therapy (ADT) in the treatment of metastatic prostate… read more here.
Keywords: adt; treatment; hormone sensitive; metastatic hormone ... See more keywords
Updated Guidelines for Metastatic Hormone-sensitive Prostate Cancer: Abiraterone Acetate Combined with Castration Is Another Standard.
Sign Up to like & getrecommendations! Published in 2017 at "European urology"
DOI: 10.1016/j.eururo.2017.09.029
Abstract: Addition of docetaxel to androgen deprivation therapy (ADT) was recommended for patients with newly diagnosed metastatic hormone-sensitive prostate cancer (mHSPC), who are fit enough to receive docetaxel. Two recently published trials showed that the addition… read more here.
Keywords: abiraterone acetate; prostate cancer; hormone sensitive; metastatic hormone ... See more keywords
Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64043-4
Abstract: Aggression is a sexually dimorphic behaviour. In some species, including the laboratory mouse, it is robustly expressed in males – while females are not aggressive in the non-puerperal state. However, during nursing, females exhibit maternal… read more here.
Keywords: dormant hormone; circuit; aggression; hormone sensitive ... See more keywords
Identification of a Radiosensitivity Molecular Signature Induced by Enzalutamide in Hormone-sensitive and Hormone-resistant Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44991-w
Abstract: Prostate cancer (PCa) is the most common cancer amongst men. A novel androgen receptor (AR) antagonist, enzalutamide (ENZA) has recently been demonstrated to enhance the effect of radiation (XRT) by impairing the DNA damage repair… read more here.
Keywords: hormone; hormone resistant; prostate cancer; hormone sensitive ... See more keywords