Development of a Zebrafish Embryo-Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research.
Sign Up to like & getrecommendations! Published in 2024 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5878
Abstract: There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system-disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co-operation… read more here.
Keywords: system; chemistry; thyroid hormone; hormone system ... See more keywords
Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.10.010
Abstract: Disruption of the thyroid hormone system during development can impair brain development and cause irreversible damage. Some thyroid hormone system disruptors act by inhibiting the thyroperoxidase (TPO) enzyme, which is key to thyroid hormone synthesis.… read more here.
Keywords: hormone; development; hormone system; thyroid hormone ... See more keywords
In Silico Identification of Potential Thyroid Hormone System Disruptors among Chemicals in Human Serum and Chemicals with a High Exposure Index
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DOI: 10.1021/acs.est.1c07762
Abstract: Data on toxic effects are at large missing the prevailing understanding of the risks of industrial chemicals. Thyroid hormone (TH) system disruption includes interferences of the life cycle of the thyroid hormones and may occur… read more here.
Keywords: system; identification potential; potential thyroid; hormone system ... See more keywords