Clearance of HIV-1 or SIV reservoirs by promotion of apoptosis and inhibition of autophagy: Targeting intracellular molecules in cure-directed strategies.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.4mr0222-606
Abstract: The reservoirs of the HIV display cellular properties resembling long-lived immune memory cells that could be exploited for viral clearance. Our interest in developing a cure for HIV stems from the studies of immunologic memory… read more here.
Keywords: hiv siv; hiv; clearance hiv; siv reservoirs ... See more keywords
Chlamydia abortus OmcB protein is essential for adhesion to host cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202100312
Abstract: Chlamydia abortus (C. abortus) is one of the most important zoonotic pathogens, causing a number of serious diseases. The adhesion of C. abortus to host cells is the first and crucial step in the process… read more here.
Keywords: abortus; omcb protein; omcb; host cells ... See more keywords
Magnetofection™ of NMDA Receptor Subunits GluN1 and GluN2A Expression Vectors in Non-Neuronal Host Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7321-7_5
Abstract: The functional study of reconstituted NMDA receptors (NMDARs) in host cells requires that the corresponding vectors for the expression of the NMDAR subunits are co-transfected with high efficiency. Magnetofection™ is a technology used to deliver… read more here.
Keywords: host cells; magnetofection nmda; expression; host ... See more keywords
Seeking and destroying the evils from the inside-translating cancer immunity to fight COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02580-1
Abstract: Facing the current COVID-19 pandemic around the world, we are eagerly looking for protection and cure for this infectious disease. Certain uncertainties we are facing are: (1) to what degree our immune system can provide… read more here.
Keywords: immunity; antibody; host cells; covid ... See more keywords
Targeting infected host cells in vivo via responsive azido-sugar mediated metabolic cell labeling followed by click reaction.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119843
Abstract: The early in vivo diagnosis of infectious disease foci is largely hindered by invasion and concealment of pathogens in host cells, making it difficult for conventional probes to detect and analyze intracellular pathogens. Taking advantage… read more here.
Keywords: cells vivo; infected host; host cells; targeting infected ... See more keywords
Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells.
Sign Up to like & getrecommendations! Published in 2021 at "Immunity"
DOI: 10.1016/j.immuni.2021.09.021
Abstract: Nitric oxide (NO) is an important antimicrobial effector but also prevents unnecessary tissue damage by shutting down the recruitment of monocyte-derived phagocytes. Intracellular pathogens such as Leishmania major can hijack these cells as a niche… read more here.
Keywords: recruitment; host cells; proliferation; permissive host ... See more keywords
Aging: An evolutionary competition between host cells and mitochondria.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.04.007
Abstract: Here, a new theory of aging is proposed. This new theory is referred as the Host-Mitochondria Intracellular Innate Immune Theory of Aging (HMIIITA). The main point of this theory is that the aging is rooted… read more here.
Keywords: cells mitochondria; theory; host cells; evolutionary competition ... See more keywords
Molecular detection of Hsp90 inhibitor suppressing PCV2 replication in host cells.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.04.037
Abstract: Porcine Circovirus Type 2 (PCV2) is a pathogen that has the ability to cause devastating disease manifestations in pig populations with major economic implications. Our previous research found that Hsp90 is required for PCV2 production… read more here.
Keywords: hsp90; pcv2; host cells; pcv2 replication ... See more keywords
Modulation of type I interferon signaling by African swine fever virus (ASFV) of different virulence L60 and NHV in macrophage host cells.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2018.02.008
Abstract: ASFV causes an important disease of domestic swine and wild boar. Currently no vaccine is available, highlighting the necessity to understand ASFV modulation of innate immune responses in natural host cells. With this aim, macrophage… read more here.
Keywords: modulation; host cells; interferon; l60 nhv ... See more keywords
Quantitative analyses reveal distinct sensitivities of the capture of HIV-1 primary viruses and pseudoviruses to broadly neutralizing antibodies.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2017.05.015
Abstract: Development of vaccines capable of eliciting broadly neutralizing antibodies (bNAbs) is a key goal to controlling the global AIDS epidemic. To be effective, bNAbs must block the capture of HIV-1 to prevent viral acquisition and… read more here.
Keywords: quantitative analyses; host cells; neutralizing antibodies; primary viruses ... See more keywords
Ezetimibe blocks Toxoplasma gondii-, Neospora caninum- and Besnoitia besnoiti-tachyzoite infectivity and replication in primary bovine endothelial host cells
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology"
DOI: 10.1017/s0031182021000822
Abstract: Abstract Abstract Coccidia are obligate apicomplexan parasites that affect humans and animals. In fast replicating species, in vitro merogony takes only 24–48 h. In this context, successful parasite proliferation requires nutrients and other building blocks.… read more here.
Keywords: toxoplasma gondii; gondii neospora; neospora caninum; caninum besnoitia ... See more keywords