Nanozyme-Based Supramolecular Self-Assembly As an Artificial Host Defense System For Treatment of Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301096
Abstract: The proper functioning of host defense system (HDS) is the key to combating bacterial infection in biological organisms. However, the delicate HDS may be dysfunctional or dysregulated, resulting in persistent infection, tissue damage, or delayed… read more here.
Keywords: host defense; system; defense system; treatment ... See more keywords
Calorimetry Methods to Study Membrane Interactions and Perturbations Induced by Antimicrobial Host Defense Peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6737-7_9
Abstract: Biological membranes play an important role in determining the activity and selectivity of antimicrobial host defense peptides (AMPs). Several biophysical methods have been developed to study the interactions of AMPs with biological membranes. Isothermal titration… read more here.
Keywords: methods study; defense peptides; host defense; membrane interactions ... See more keywords
Rabbit’s Host Defense Peptide (RSRAH) Protects Mice from Escherichia coli Challenge
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9694-9
Abstract: Host defense peptides (HDPs) are evolutionarily conserved molecules that protect the host against microbial infections and inflammation. Rabbit sacculus rotundus antimicrobial histone (RSRAH), which was identified as a novel antimicrobial HDP, has been shown to… read more here.
Keywords: coli challenge; rsrah; escherichia coli; host defense ... See more keywords
Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.029
Abstract: The antineoplastic activity of host defense peptide Hymenochirin-1B, has been extensively studied. However, the mechanism still remains unknown. In this study, linear peptide, Hymenochirin-1B, was synthesized via solid-phase peptide synthesis and evaluated for its anticancer… read more here.
Keywords: apoptosis; defense peptide; peptide hymenochirin; host defense ... See more keywords
Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.013
Abstract: The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In… read more here.
Keywords: physiology; immune system; system; host defense ... See more keywords
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.03.040
Abstract: Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is categorized as an executioner caspase but shows key differences from the other executioners. Overall, little is known about the functions of caspase-6 in biological processes… read more here.
Keywords: caspase; inflammasome activation; host defense; activation ... See more keywords
A defective release of host defense peptides is present in canine atopic skin.
Sign Up to like & getrecommendations! Published in 2019 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2019.04.008
Abstract: The use of dogs as animal model for human atopic dermatitis (AD) is well known. Striking similarities in the pathogenesis of AD have been demonstrated. Similar alteration of host defense peptides (HDP) have been identified… read more here.
Keywords: host defense; defense peptides; skin; atopic ... See more keywords
ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2021.03.001
Abstract: Autosomal recessive mutations in Inducible T Cell Costimulator Ligand (ICOSLG) result in a combined immunodeficiency syndrome of humans, saliently marked by recurrent respiratory tract infections and significant disease with DNA-based viruses at epithelial barriers, including… read more here.
Keywords: icosl host; icosl icos; host defense; epithelial barriers ... See more keywords
An orthologue of the host‐defense protein psoriasin (S100A7) is expressed in frog skin
Sign Up to like & getrecommendations! Published in 2017 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2016.08.012
Abstract: ABSTRACT Host‐defense peptides and proteins are vital for first line protection against bacteria. Most host‐defense peptides and proteins common in vertebrates have been studied primarily in mammals, while their orthologues in non‐mammalian vertebrates received less… read more here.
Keywords: protein; host defense; s100a7; skin ... See more keywords
An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin‐Bearing Influenza Viruses
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.03.018
Abstract: &NA; Although vaccines confer protection against influenza A viruses, antiviral treatment becomes the first line of defense during pandemics because there is insufficient time to produce vaccines. Current antiviral drugs are susceptible to drug resistance,… read more here.
Keywords: influenza; host defense; hemagglutinin bearing; influenza viruses ... See more keywords
LC-MS/MS assay coupled with carboxylic acid magnetic bead affinity capture to quantitatively measure cationic host defense peptides (HDPs) in complex matrices with application to preclinical pharmacokinetic studies.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113093
Abstract: Synthetic host defense peptides (HDP) are a new class of promising therapeutic agents with potential application in a variety of diseases. RP-182 is a 10mer synthetic HDP design, which selectively reduces M2-like tumor associated macrophages… read more here.
Keywords: acid magnetic; defense; defense peptides; carboxylic acid ... See more keywords