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   Articles with "host defense" as a keyword



Imidazole‐Rich, Four‐Armed Host‐Defense Peptidomimetics as Promising Narrow‐Spectrum Antibacterial Agents and Adjuvants against Pseudomonas Aeruginosa Infections

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recommendations! Published in 2024 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202400664

Abstract: The development of narrow‐spectrum antimicrobial agents is paramount for swiftly eradicating pathogenic bacteria, mitigating the onset of drug resistance, and preserving the homeostasis of bacterial microbiota in tissues. Owing to the limited affinity between the… read more here.

Keywords: four armed; armed host; host defense; imidazole rich ... See more keywords

Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202308890

Abstract: Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor… read more here.

Keywords: activation; host defense; sting irf3; cgas sting ... See more keywords

Hydrocarbon Stapling Enables Improvement of Antimicrobial Activity and Proteolytic Stability of Host‐Defense Peptide Ocellatin‐3N

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recommendations! Published in 2025 at "ChemBioChem"

DOI: 10.1002/cbic.202500204

Abstract: Ocellatin‐3N is a cationic, amphiphilic host‐defense peptide with 19 residues, which is isolated from the Caribbean frog Leptodactylus nesiotus. Its analogue Oce‐3N‐0 shows potent inhibitory activity against both Gram‐negative and Gram‐positive pathogens, and has great… read more here.

Keywords: host defense; peptide; antimicrobial activity; defense peptide ... See more keywords

Nanozyme-Based Supramolecular Self-Assembly As an Artificial Host Defense System For Treatment of Bacterial Infections.

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recommendations! Published in 2023 at "Small"

DOI: 10.1002/smll.202301096

Abstract: The proper functioning of host defense system (HDS) is the key to combating bacterial infection in biological organisms. However, the delicate HDS may be dysfunctional or dysregulated, resulting in persistent infection, tissue damage, or delayed… read more here.

Keywords: host defense; system; defense system; treatment ... See more keywords

Calorimetry Methods to Study Membrane Interactions and Perturbations Induced by Antimicrobial Host Defense Peptides.

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recommendations! Published in 2017 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-6737-7_9

Abstract: Biological membranes play an important role in determining the activity and selectivity of antimicrobial host defense peptides (AMPs). Several biophysical methods have been developed to study the interactions of AMPs with biological membranes. Isothermal titration… read more here.

Keywords: methods study; defense peptides; host defense; membrane interactions ... See more keywords

Rabbit’s Host Defense Peptide (RSRAH) Protects Mice from Escherichia coli Challenge

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recommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"

DOI: 10.1007/s10989-018-9694-9

Abstract: Host defense peptides (HDPs) are evolutionarily conserved molecules that protect the host against microbial infections and inflammation. Rabbit sacculus rotundus antimicrobial histone (RSRAH), which was identified as a novel antimicrobial HDP, has been shown to… read more here.

Keywords: coli challenge; rsrah; escherichia coli; host defense ... See more keywords

Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.03.029

Abstract: The antineoplastic activity of host defense peptide Hymenochirin-1B, has been extensively studied. However, the mechanism still remains unknown. In this study, linear peptide, Hymenochirin-1B, was synthesized via solid-phase peptide synthesis and evaluated for its anticancer… read more here.

Keywords: apoptosis; defense peptide; peptide hymenochirin; host defense ... See more keywords
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Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.03.013

Abstract: The essential roles played by the immune system in the discrimination between self- versus non/altered-self and its integral role in promoting host defense against invading microbes and tumors have been extensively studied for many years. In… read more here.

Keywords: physiology; immune system; system; host defense ... See more keywords
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Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

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recommendations! Published in 2020 at "Cell"

DOI: 10.1016/j.cell.2020.03.040

Abstract: Caspases regulate cell death, immune responses, and homeostasis. Caspase-6 is categorized as an executioner caspase but shows key differences from the other executioners. Overall, little is known about the functions of caspase-6 in biological processes… read more here.

Keywords: caspase; inflammasome activation; host defense; activation ... See more keywords

A defective release of host defense peptides is present in canine atopic skin.

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recommendations! Published in 2019 at "Comparative immunology, microbiology and infectious diseases"

DOI: 10.1016/j.cimid.2019.04.008

Abstract: The use of dogs as animal model for human atopic dermatitis (AD) is well known. Striking similarities in the pathogenesis of AD have been demonstrated. Similar alteration of host defense peptides (HDP) have been identified… read more here.

Keywords: host defense; defense peptides; skin; atopic ... See more keywords

ICOSL in host defense at epithelial barriers: lessons from ICOSLG deficiency.

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recommendations! Published in 2021 at "Current opinion in immunology"

DOI: 10.1016/j.coi.2021.03.001

Abstract: Autosomal recessive mutations in Inducible T Cell Costimulator Ligand (ICOSLG) result in a combined immunodeficiency syndrome of humans, saliently marked by recurrent respiratory tract infections and significant disease with DNA-based viruses at epithelial barriers, including… read more here.

Keywords: icosl host; icosl icos; host defense; epithelial barriers ... See more keywords