Host-Dependent Improvement of GFP Expression in Pseudomonas putida KT2440 Using Terminators of Metagenomic Origin.
Sign Up to like & getrecommendations! Published in 2023 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.3c00098
Abstract: Transcriptional terminators are key players in the flow of genetic information, but are often overlooked in circuit design. In this work, we used the Standard European Vector Architecture (SEVA) as a scaffold to investigate the… read more here.
Keywords: improvement; putida kt2440; expression; host dependent ... See more keywords
Host-Dependent Phenotypic Resistance to EGFR Tyrosine Kinase Inhibitors
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DOI: 10.1158/0008-5472.can-20-3555
Abstract: This study reports that stepwise acquisition of kinase inhibitor resistance in lung cancers driven by mutant EGFR comprises a nonmutational, reversible resister state. Lung cancers driven by mutant forms of EGFR invariably develop resistance to… read more here.
Keywords: host dependent; kinase; resistance egfr; resistance ... See more keywords
RpoS contributes in a host-dependent manner to Salmonella colonization of the leaf apoplast during plant disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.999183
Abstract: Contaminated fresh produce has been routinely linked to outbreaks of Salmonellosis. Multiple studies have identified Salmonella enterica factors associated with successful colonization of diverse plant niches and tissues. It has also been well documented that… read more here.
Keywords: colonization; plant disease; plant; host dependent ... See more keywords
Characterization of Three Variants of SARS-CoV-2 In Vivo Shows Host-Dependent Pathogenicity in Hamsters, While Not in K18-hACE2 Mice
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DOI: 10.3390/v14112584
Abstract: Animal models are used in preclinical trials to test vaccines, antivirals, monoclonal antibodies, and immunomodulatory drug therapies against SARS-CoV-2. However, these drugs often do not produce equivalent results in human clinical trials. Here, we show… read more here.
Keywords: k18 hace2; animal models; hace2 mice; mice ... See more keywords
Host-Dependent Modifications of Packaged Alphavirus Genomic RNA Influence Virus Replication in Mammalian Cells
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DOI: 10.3390/v14122606
Abstract: Alphaviruses must interact efficiently with two distinct host environments in order to replicate and transmit between vertebrate and mosquito hosts. Some host-origin-dependent differences in virus particle composition that appear to facilitate the transmission cycle are… read more here.
Keywords: genomic rna; replication; rna; host dependent ... See more keywords