Host-directed editing of the SARS-CoV-2 genome
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and Biophysical Research Communications"
DOI: 10.1016/j.bbrc.2020.10.092
Abstract: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on… read more here.
Keywords: genome host; host directed; directed editing; cov genome ... See more keywords
Host-directed therapies to combat tuberculosis and associated non-communicable diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.03.003
Abstract: Mycobacterium tuberculosis (Mtb) has coevolved with a human host to evade and exploit the immune system in multiple ways. Mtb is an enormously successful human pathogen that can remain undetected in hosts for decades without… read more here.
Keywords: communicable diseases; non communicable; host directed; directed therapies ... See more keywords
Metformin as a host-directed therapeutic in tuberculosis: Is there a promise?
Sign Up to like & getrecommendations! Published in 2019 at "Tuberculosis"
DOI: 10.1016/j.tube.2019.02.004
Abstract: To complement the development of new or repurposed drugs for improving the treatment outcomes of drug-susceptible and drug-resistant tuberculosis, current insight also focuses on the use of host-directed therapy. Metformin, a drug often used in… read more here.
Keywords: therapeutic tuberculosis; tuberculosis; metformin host; directed therapeutic ... See more keywords
The use of thalidomide to treat children with tuberculosis meningitis: A review.
Sign Up to like & getrecommendations! Published in 2021 at "Tuberculosis"
DOI: 10.1016/j.tube.2021.102125
Abstract: Much of the morbidity and mortality caused by tuberculous meningitis (TBM) is mediated by a dysregulated immune response. Effective host-directed therapy is therefore critical to improve survival and clinical outcomes. Currently only one host-directed therapy… read more here.
Keywords: meningitis; directed therapy; use; host directed ... See more keywords
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01243
Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) catalyzed the development of vaccines and antivirals. Clinically approved drugs against SARS-CoV-2 target the virus directly, which makes them susceptible to viral mutations, which in… read more here.
Keywords: reactive oxygen; host directed; directed antiviral; oxygen species ... See more keywords
Therapeutic host-directed strategies to improve outcome in tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-019-0226-5
Abstract: Bacille Calmette-Guérin (BCG) is the only licenced tuberculosis (TB) vaccine, but has limited efficacy against pulmonary TB disease development and modest protection against extrapulmonary TB. Preventative antibiotic treatment for Mycobacterium tuberculosis (Mtb) infections in high-prevalence… read more here.
Keywords: improve outcome; treatment; host directed; tuberculosis ... See more keywords
Autophagy: A new strategy for host-directed therapy of tuberculosis
Sign Up to like & getrecommendations! Published in 2019 at "Virulence"
DOI: 10.1080/21505594.2018.1536598
Abstract: ABSTRACT Tuberculosis (TB), which is primarily caused by the major etiologic agent Mycobacterium tuberculosis (Mtb), remains a serious infectious disease worldwide. Recently, much effort has been made to develop novel/improved therapies by modulating host responses… read more here.
Keywords: directed therapy; host directed; tuberculosis; host ... See more keywords
Systematic optimization of host-directed therapeutic targets and preclinical validation of repositioned antiviral drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac047
Abstract: Inhibition of host protein functions using established drugs produces a promising antiviral effect with excellent safety profiles, decreased incidence of resistant variants and favorable balance of costs and risks. Genomic methods have produced a large… read more here.
Keywords: drug targets; drug; optimization; virus ... See more keywords
Host-directed immunotherapy to fight infectious diseases
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000001176
Abstract: Purpose of review This review provides readers with examples of refractory infections due to inborn errors of immunity, highlighting how they may be successfully treated by deducing and targeting the underlying immunodeficiency. Recent findings The… read more here.
Keywords: immunotherapy fight; host directed; inborn errors; directed immunotherapy ... See more keywords
Host‐directed anti‐mycobacterial activity of colchicine, an anti‐gout drug, via strengthened host innate resistance reinforced by the IL‐1β/PGE2 axis
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15838
Abstract: To diversify and expand possible tuberculosis (TB) drug candidates and maximize limited global resources, we investigated the effect of colchicine, an FDA‐approved anti‐gout drug, against Mycobacterium tuberculosis (Mtb) infection because of its immune‐modulating effects. read more here.
Keywords: host directed; anti gout; colchicine; host ... See more keywords
Host-Directed Antiviral Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Microbiology Reviews"
DOI: 10.1128/cmr.00168-19
Abstract: Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA… read more here.
Keywords: directed antiviral; drug resistant; virus; host ... See more keywords