Methylation-based enrichment facilitates low-cost, noninvasive genomic scale sequencing of populations from feces
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20427-9
Abstract: Obtaining high-quality samples from wild animals is a major obstacle for genomic studies of many taxa, particularly at the population level, as collection methods for such samples are typically invasive. DNA from feces is easy… read more here.
Keywords: methylation; host dna; dna; genomic scale ... See more keywords
Bidirectional Mediation Effects between Intratumoral Microbiome and Host DNA Methylation Changes Contribute to Stomach Adenocarcinoma
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DOI: 10.1128/spectrum.00904-23
Abstract: The burgeoning field of oncobiome research declared that members of the intratumoral microbiome besides Helicobacter pylori existed in tumor tissues and participated in the occurrence and development of gastric cancer, and the methylation of host… read more here.
Keywords: methylation; intratumoral microbiome; host; cancer ... See more keywords
Benchmarking microbial DNA enrichment protocols from human intestinal biopsies
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1184473
Abstract: Shotgun metagenomic sequencing is a powerful tool for studying bacterial communities in their natural habitats or sites of infection, without the need for cultivation. However, low microbial signals in metagenomic sequencing can be overwhelmed by… read more here.
Keywords: dna enrichment; dna; host dna; human intestinal ... See more keywords
Host DNA depletion can increase the sensitivity of Mycobacterium spp. detection through shotgun metagenomics in sputum
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.949328
Abstract: Identification and phenotypic drug-susceptibility testing for mycobacteria are time-consuming and challenging but essential for managing mycobacterial infections. Next-generation sequencing (NGS) technologies can increase diagnostic speed and quality, but standardization is still lacking for many aspects… read more here.
Keywords: dna; sensitivity; depletion; detection ... See more keywords
The Interplay between Viruses and Host DNA Sensors
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DOI: 10.3390/v14040666
Abstract: DNA virus infections are often lifelong and can cause serious diseases in their hosts. Their recognition by the sensors of the innate immune system represents the front line of host defence. Understanding the molecular mechanisms… read more here.
Keywords: dna; interplay viruses; dna sensors; viruses host ... See more keywords
Cross-Regulation between Transposable Elements and Host DNA Replication
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DOI: 10.3390/v9030057
Abstract: Transposable elements subvert host cellular functions to ensure their survival. Their interaction with the host DNA replication machinery indicates that selective pressures lead them to develop ancestral and convergent evolutionary adaptations aimed at conserved features… read more here.
Keywords: transposable elements; dna replication; host; host dna ... See more keywords