A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16517-w
Abstract: Chronic HBV infection is a major cause of liver disease and cancer worldwide. Approaches for cure are lacking, and the knowledge of virus-host interactions is still limited. Here, we perform a genome-wide gain-of-function screen using… read more here.
Keywords: hbv; function screen; host factor; host ... See more keywords
AHR is a Zika virus host factor and a candidate target for antiviral therapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Neuroscience"
DOI: 10.1038/s41593-020-0664-0
Abstract: Zika virus (ZIKV) is a flavivirus linked to multiple birth defects including microcephaly, known as congenital ZIKV syndrome. The identification of host factors involved in ZIKV replication may guide efficacious therapeutic interventions. In genome-wide transcriptional… read more here.
Keywords: ahr; host factor; zika virus; replication ... See more keywords
Integration host factor bends and bridges DNA in a multiplicity of binding modes with varying specificity
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab641
Abstract: Abstract Nucleoid-associated proteins (NAPs) are crucial in organizing prokaryotic DNA and regulating genes. Vital to these activities are complex nucleoprotein structures, however, how these form remains unclear. Integration host factor (IHF) is an Escherichia coli… read more here.
Keywords: integration host; binding modes; host factor; dna ... See more keywords
Differential hepatitis C virus RNA target site selection and host factor activities of naturally occurring miR-122 3΄ variants
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1332
Abstract: Abstract In addition to suppressing cellular gene expression, certain miRNAs potently facilitate replication of specific positive-strand RNA viruses. miR-122, a pro-viral hepatitis C virus (HCV) host factor, binds and recruits Ago2 to tandem sites (S1… read more here.
Keywords: rna; hcv; host factor; mir 122 ... See more keywords
NF90–NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx931
Abstract: Abstract The heterodimer NF90–NF45 is an RNA-binding protein complex that modulates the expression of various cellular mRNAs on the post-transcriptional level. Furthermore, it acts as a host factor that supports the replication of several RNA… read more here.
Keywords: rna; nf90 nf45; host factor; rna chaperone ... See more keywords
Reciprocally rewiring and repositioning the Integration Host Factor (IHF) subunit genes in Salmonella enterica serovar Typhimurium: impacts on physiology and virulence
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000768
Abstract: The Integration Host Factor (IHF) is a heterodimeric nucleoid-associated protein that plays roles in bacterial nucleoid architecture and genome-wide gene regulation. The ihfA and ihfB genes encode the subunits and are located 350 kbp apart,… read more here.
Keywords: integration host; salmonella; factor ihf; physiology ... See more keywords
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.02.26.482111
Abstract: Oropouche orthobunyavirus (OROV; Peribunyaviridae) is a mosquito-transmitted virus that causes widespread cases of human febrile illness in South America, with occasional progression to neurologic effects. Host entry factors mediating cellular entry of OROV are undefined.… read more here.
Keywords: lrp1; infection; host factor; oropouche orthobunyavirus ... See more keywords
Neuropilin-1 is a host factor for SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abd3072
Abstract: Another host factor for SARS-CoV-2 Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their… read more here.
Keywords: factor sars; host factor; host; sars cov ... See more keywords
The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00731-22
Abstract: In this study, we discover the tetraspanin CD81 as a host factor for the globally emerging chikungunya virus and related alphaviruses. We show that CD81 promotes replication of viral genomes in human and mouse cells,… read more here.
Keywords: cd81; replication; virus; host factor ... See more keywords
Integration Host Factor Modulates the Expression and Function of T6SS2 in Vibrio fluvialis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00962
Abstract: Vibrio fluvialis, an emerging foodborne pathogen of increasing public health concern, contains two distinct gene clusters encoding type VI secretion system (T6SS), the most newly discovered secretion pathway in Gram-negative bacteria. Previously we have shown… read more here.
Keywords: integration host; host factor; vibrio fluvialis; modulates expression ... See more keywords
Specialization of the Reiterated Copies of the Heterodimeric Integration Host Factor Genes in Geobacter sulfurreducens
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.626443
Abstract: Integration host factor (IHF) is a widely distributed small heterodimeric protein member of the bacterial Nucleoid-Associated Proteins (NAPs), implicated in multiple DNA regulatory processes. IHF recognizes a specific DNA sequence and induces a large bend… read more here.
Keywords: integration host; host factor; ihfa ihfb; ihf ... See more keywords