Regulatory networks and 5′ partner usage of miRNA host gene fusions in breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33972
Abstract: Genomic rearrangements in cancer cells can create gene fusions where the juxtaposition of two different genes leads to the production of chimeric proteins or altered gene expression through promoter‐swapping. We have previously shown that fusion… read more here.
Keywords: mirna host; cancer; gene fusions; host gene ... See more keywords
Correlation of small nucleolar RNA host gene 16 with acute respiratory distress syndrome occurrence and prognosis in sepsis patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24516
Abstract: Long noncoding RNA small nucleolar RNA host gene 16 (lnc‐SNHG16) regulates sepsis‐induced acute lung injury and inflammation, which is involved in the pathophysiology of acute respiratory distress syndrome (ARDS). The present study intended to explore… read more here.
Keywords: sepsis; small nucleolar; nucleolar rna; host gene ... See more keywords
The clever strategies used by intracellular parasites to hijack host gene expression
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-020-00779-z
Abstract: Intracellular pathogens need to develop sophisticated mechanisms to survive and thrive in the hostile environment within host cells. Unicellular, eukaryotic parasites from the Apicomplexa phylum have become masters of manipulating their host cells, exploiting signaling,… read more here.
Keywords: gene expression; hijack host; host; gene ... See more keywords
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25179
Abstract: Transposable elements, also known as transposons, are now recognized not only as parasitic DNA, the spread of which in the genome must be controlled by the host, but also as major players in genome evolution… read more here.
Keywords: genome wide; silencing euchromatic; euchromatic l1s; l1s ... See more keywords
LEADeR role of miR-205 host gene as long noncoding RNA in prostate basal cell differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08153-2
Abstract: Though miR-205 function has been largely characterized, the nature of its host gene, MIR205HG, is still completely unknown. Here, we show that only lowly expressed alternatively spliced MIR205HG transcripts act as de facto pri-miRNAs, through… read more here.
Keywords: prostate; mir 205; differentiation; host gene ... See more keywords
Expression of the miR-302/367 microRNA cluster is regulated by a conserved long non-coding host-gene
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89080-z
Abstract: MicroRNAs are important regulators of cellular functions. MiR-302/367 is a polycistronic miRNA cluster that can induce and maintain pluripotency. Here we investigate the transcriptional control and the processing of the miR-302 host-gene in mice. Our… read more here.
Keywords: 302 367; mir 302; long non; gene ... See more keywords
Host gene effects on gut microbiota in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220004
Abstract: Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by progressive pancreatic β-cell loss. Both a predisposing genetic background, that may encompass mutations in several genes, as well as exposure to environmental factors can… read more here.
Keywords: host gene; t1d; type diabetes; gut microbiota ... See more keywords
The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205013119
Abstract: Significance All positive-sense single-stranded RNA viruses, such as Zika virus (ZIKV), replicate in the cytoplasm of host cells, but they can regulate host gene expression in the nucleus. Here, we report that the ZIKV NS5,… read more here.
Keywords: dna; transcription; zikv; host gene ... See more keywords
MIR205 host gene (MIR205HG) drives osteosarcoma metastasis via regulating the microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1920326
Abstract: Osteosarcoma (OS) is an aggressive malignant tumor with a high rate of lung metastasis and a lack of therapeutic targets. Although the anomalous expression of long non-coding RNA (lncRNA) has been extensively documented in human… read more here.
Keywords: metastasis; gene mir205hg; mir205 host; mir 2114 ... See more keywords
The role of long non-coding RNA SNHG12 in neuroprotection following cerebral ischemic injury.
Sign Up to like & getrecommendations! Published in 2019 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001308
Abstract: As one of the major causes of mortality and disability worldwide, ischemic stroke has never been received enough attention. Following ischemia/reperfusion injury, long non-coding RNAs have been extensively found to be involved into inflammatory responses,… read more here.
Keywords: host gene; nucleolar rna; small nucleolar; rna ... See more keywords
Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaz0802
Abstract: Single-cell transcriptome analysis by HIV-1 SortSeq identifies HIV-1–driven aberrant host gene transcription as a mechanism of HIV-1 persistence. Sorting out HIV The latent reservoir of HIV-1–infected cells that persist in, otherwise, virally suppressed individuals constitutes… read more here.
Keywords: hiv; gene transcription; aberrant host; host ... See more keywords