When 3D genome technology meets viral infection, including SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28040
Abstract: Mammalian chromosomes undergo varying degrees of compression to form three‐dimensional genome structures. These three‐dimensional structures undergo dynamic and precise chromatin interactions to achieve precise spatial and temporal regulation of gene expression. Most eukaryotic DNA viruses… read more here.
Keywords: technology; host genome; genome; three dimensional ... See more keywords
Host Genome Variation is Associated with Neurocognitive Outcome in Survivors of Pediatric Medulloblastoma1
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2019.03.004
Abstract: Host genome analysis is a promising source of predictive information for long-term morbidity in cancer survivors. However, studies on genetic predictors of long-term outcome, particularly neurocognitive function following chemoradiation in pediatric oncology, are limited. Here,… read more here.
Keywords: outcome; long term; host genome; oncology ... See more keywords
Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease
Sign Up to like & getrecommendations! Published in 2018 at "Clinical and Translational Gastroenterology"
DOI: 10.1038/ctg.2017.58
Abstract: Objectives:Inflammatory bowel diseases (IBD), comprised of Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in… read more here.
Keywords: risk; inflammatory bowel; host genome; gut microbiome ... See more keywords
LINE-1 repression in Epstein-Barr virus-associated gastric cancer through viral-host genome interaction.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad203
Abstract: Long INterspersed Element 1 (LINE-1 or L1) acts as a major remodeling force in genome regulation and evolution. Accumulating evidence shows that virus infection impacts L1 expression, potentially impacting host antiviral response and diseases. The… read more here.
Keywords: host genome; viral host; genome interaction; gastric cancer ... See more keywords
Coadaptation between host genome and microbiome under long-term xenobiotic-induced selection
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abd4473
Abstract: Long-term host microbiome structure selection drives host genome evolution and adaptation. One of the most difficult experimental challenges today is testing the evolutionary dynamics shaping complex host-microbiome interactions. We investigated host-microbiome codiversification in response to… read more here.
Keywords: xenobiotic induced; induced selection; microbiome; host genome ... See more keywords
Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008633
Abstract: DNA viruses can hijack and manipulate the host chromatin state to facilitate their infection. Multiple lines of evidences reveal that DNA virus infection results in the host chromatin relocation, yet there is little known about… read more here.
Keywords: chromatin; infection; host genome; chromatin accessibility ... See more keywords
Dynamics of Viral and Host 3D Genome Structure upon Infection
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Microbiology and Biotechnology"
DOI: 10.4014/jmb.2208.08020
Abstract: Eukaryotic chromatin is highly organized in the 3D nuclear space and dynamically regulated in response to environmental stimuli. This genomic organization is arranged in a hierarchical fashion to support various cellular functions, including transcriptional regulation… read more here.
Keywords: structure; host genome; infection; dynamics viral ... See more keywords