Articles with "host microbe" as a keyword



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Chemical Proteomics of Host–Microbe Interactions

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Published in 2018 at "PROTEOMICS"

DOI: 10.1002/pmic.201700333

Abstract: The dynamic proteome plays numerous roles in the interactions of microbes—whether they are invading pathogens or symbiotic organisms—and their hosts. Host and microbe sense, respond, and manipulate each other's biology via a multitude of mechanisms,… read more here.

Keywords: proteomics host; microbe; chemical proteomics; microbe interactions ... See more keywords

The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut.

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Published in 2017 at "Anaerobe"

DOI: 10.1016/j.anaerobe.2017.01.001

Abstract: The microbiota of the gut has many crucial functions in human health. Dysbiosis of the microbiota has been correlated to a large and still increasing number of diseases. Recent studies have mostly focused on analyzing… read more here.

Keywords: gut; human gut; disease; host microbe ... See more keywords
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Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

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Published in 2019 at "Cell"

DOI: 10.1016/j.cell.2019.08.003

Abstract: Summary Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address the fundamental question of how gut microbes and nutrition, key regulators of host physiology,… read more here.

Keywords: metformin; drug; drug nutrient; host microbe ... See more keywords
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Host–Microbe Interactions: Winning the Colonization Lottery

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Published in 2017 at "Current Biology"

DOI: 10.1016/j.cub.2017.05.068

Abstract: Stochastic bottlenecks during bacterial colonization of animal hosts lead to reduced genetic diversity in the resulting microbiota and, at low-inoculation doses, can result in hosts that remain uncolonized. Bacterial strains vary in their colonization efficiency… read more here.

Keywords: colonization lottery; microbe interactions; colonization; host microbe ... See more keywords

Resolving host-microbe interactions in the gut: the promise of in vitro models to complement in vivo research.

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Published in 2018 at "Current opinion in microbiology"

DOI: 10.1016/j.mib.2018.07.001

Abstract: While animal models remain essential for inferring causality, they exhibit important limitations, which restrict the direct translation of findings into new approaches aimed at steering host-microbe interactions for the improvement of human health. Different in… read more here.

Keywords: microbe; microbe interactions; interactions gut; host microbe ... See more keywords
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Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe.

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Published in 2018 at "Methods"

DOI: 10.1016/j.ymeth.2018.04.029

Abstract: It is well established that gut microbes and their metabolic products regulate host metabolism. The interactions between the host and its gut microbiota are highly dynamic and complex. In this review we present and discuss… read more here.

Keywords: gut metabolome; host microbe; host; gut microbiota ... See more keywords
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Introduction to host microbiome symbiosis in health and disease

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Published in 2020 at "Mucosal Immunology"

DOI: 10.1038/s41385-020-00365-4

Abstract: Humans share a core intestinal microbiome and yet human microbiome differs by genes, species, enterotypes (ecology), and gene count (microbial diversity). Achievement of microbiota metagenomic analysis has revealed that the microbiome gene count is a… read more here.

Keywords: symbiosis; introduction host; microbe symbiosis; host microbe ... See more keywords

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

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Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-45855-2

Abstract: Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions,… read more here.

Keywords: mucosal; microbe interactions; host microbe; microbiota ... See more keywords
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A salivary metabolite signature that reflects gingival host-microbe interactions: instability predicts gingivitis susceptibility

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Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-59988-z

Abstract: Several proteins and peptides in saliva were shown to stimulate gingival wound repair, but the role of salivary metabolites in this process remains unexplored. In vitro gingival re-epithelialization kinetics were determined using unstimulated saliva samples… read more here.

Keywords: metabolite signature; microbe interactions; host microbe; signature ... See more keywords

From microbes to molecules: unveiling host-microbe interactions with spatial metabolomics

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Published in 2025 at "Molecular Systems Biology"

DOI: 10.1038/s44320-025-00129-x

Abstract: Spatial metabolomics is transforming our understanding of microbial systems by uncovering the localized molecular dynamics within complex microbial communities. By using advanced mass spectrometry imaging techniques, researchers can now visualize metabolites at the micron scale… read more here.

Keywords: microbe interactions; microbial communities; spatial metabolomics; host microbe ... See more keywords

Therapeutic delivery of CCL2 modulates immune response and restores host–microbe homeostasis

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Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2400528121

Abstract: Significance Periodontal disease (PD) is one of the most common inflammatory diseases caused by bacterial biofilm changes on teeth surfaces. These changes trigger an uncontrolled and destructive local host response. PD is one of the… read more here.

Keywords: ccl2; delivery; response; host microbe ... See more keywords