Integrated Host-Pathogen Metabolic Reconstructions.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7528-0_9
Abstract: The science and art of Genome scale metabolic network reconstructions have been explicitly documented in the literature for organisms across all the three kingdoms of life. Constraints-based models derived from such reconstructions have been used… read more here.
Keywords: pathogen; integrated host; biology; host ... See more keywords
Role of Mitochondria in Host-Pathogen Interaction.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8367-0_3
Abstract: The centrality of the mitochondrion in the evolution and control of the cellare now supported by many experimental studies. Not only with regard to the energy metabolism but also and especially with regard to the… read more here.
Keywords: role mitochondria; pathogen interaction; host; interaction ... See more keywords
In silico characterization, docking, and simulations to understand host–pathogen interactions in an effort to enhance crop production in date palms
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-021-04957-0
Abstract: Food safety remains a significant challenge despite the growth and development in agricultural research and the advent of modern biotechnological and agricultural tools. Though the agriculturist struggles to aid the growing population’s needs, many pathogen-based… read more here.
Keywords: pathogen; silico characterization; production; host ... See more keywords
The functional relevance of shrimp C-type lectins in host-pathogen interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103708
Abstract: C-type lectins (CTLs) are key recognition proteins in shrimp immunity. A few years ago we reviewed sequence information, ligand specificity, expression profiles and specific functions of the shrimp CTLs. Since then, multiple integrated studies that… read more here.
Keywords: functional relevance; host pathogen; type lectins; pathogen interactions ... See more keywords
Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2020.06.004
Abstract: Intrinsic disorder in proteins resulting in considerable variation in structure can lead to multiple functions including multi-specificity and diverse pathologies. Protein interfaces can involve disordered regions that assemble through a concerted-fold-and-bind mechanism. The binding involves… read more here.
Keywords: intrinsic disorder; disorder; drug design; host pathogen ... See more keywords
Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.08.001
Abstract: The molecular evolution of the adaptive response at the host-pathogen interface has been frequently referred to as an 'arms race' between the host and bacterial pathogens. The innate immune system employs multiple strategies to starve… read more here.
Keywords: evolution; molecular evolution; transition; metal ... See more keywords
Pharmacological Targeting of the Host-Pathogen Interaction: Alternatives to Classical Antibiotics to Combat Drug-Resistant Superbugs.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2017.02.003
Abstract: The rise of multidrug-resistant pathogens and the dearth of new antibiotic development place an existential strain on successful infectious disease therapy. Breakthrough strategies that go beyond classical antibiotic mechanisms are needed to combat this looming… read more here.
Keywords: pathogen; pathogen interaction; host; pharmacological targeting ... See more keywords
Stronger together
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Microbiology"
DOI: 10.1038/nrmicro.2017.95
Abstract: Susceptibility to infectious diseases and disease severity may be affected by interactions between the genomes of the host and pathogen. Although the effect of variations in gene sequence on disease has been studied for several… read more here.
Keywords: analysis; stronger together; genome; host pathogen ... See more keywords
Conserved host-pathogen interactions identify novel treatment options in betacoronavirus infections
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00480-z
Abstract: In a recent study published in Science, Gordon et al. investigate the host-pathogen interactome of the coronaviruses SARS-CoV-1, SARS-CoV-2, and MERS-CoV, all of which caused lethal outbreaks in the past two decades. They functionally characterize… read more here.
Keywords: treatment; study; host; interaction ... See more keywords
Mapping the drivers of within-host pathogen evolution using massive data sets
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10724-w
Abstract: Differences among hosts, resulting from genetic variation in the immune system or heterogeneity in drug treatment, can impact within-host pathogen evolution. Genetic association studies can potentially identify such interactions. However, extensive and correlated genetic population… read more here.
Keywords: host pathogen; within host; host; pathogen evolution ... See more keywords
A novel method for genome-wide profiling of dynamic host-pathogen interactions using 3′ end enriched RNA-seq
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08700-9
Abstract: Marek’s disease is a contagious lymphoproliferative disease of chickens and typical model of viral oncogenesis. Mapping changes or different states over the course of infection for both host and pathogen would provide important insights into… read more here.
Keywords: end enriched; dynamic host; host; host pathogen ... See more keywords