Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53794-1
Abstract: The lack of a permissive cell culture system has limited high-resolution structures of parvovirus B19 (B19V) to virus-like particles (VLPs). In this study, we present the atomic resolution structure (2.2 Å) of authentic B19V purified from… read more here.
Keywords: parvovirus b19; host; infectious parvovirus; protease inhibitors ... See more keywords
Host protease activity classifies pneumonia etiology
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121778119
Abstract: Significance Community-acquired pneumonia (CAP) is the most common infectious cause of death worldwide. In this work, we present a panel of protease-responsive nanosensors that leverage aberrant host protease activity in pneumonia to generate a urinary… read more here.
Keywords: protease activity; host protease; etiology; protease ... See more keywords