Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.03.012
Abstract: SARS-CoV-2 is the cause of a pandemic with growing global mortality. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Integration… read more here.
Keywords: cov rna; host protein; rna host; host ... See more keywords
The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.10.055
Abstract: Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication. In this study, we identified a key role for the membrane-bending host protein Reticulon 3.1… read more here.
Keywords: protein; protein reticulon; host protein; host ... See more keywords
CD98hc in host-pathogen interactions: roles of the multifunctional host protein during infections.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuac023
Abstract: The eukaryotic protein CD98hc (also known as 4F2, FRP-1 or SLC3A2) is a membrane glycoprotein and one of the heavy chains of the family of heterodimeric amino acids transporters. It can associate with any of… read more here.
Keywords: cd98hc host; host protein; host; host pathogen ... See more keywords
313. Host Protein Biomarkers Predicting Severity of Lung Damage due to COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofab466.515
Abstract: Abstract Background Biomarkers to predict the severity of lung damage due to COVID-19 are urgently needed to inform management and treatment decisions. Our objective was to investigate the predictive value of host proteins for worsening… read more here.
Keywords: icu; covid; host; lung damage ... See more keywords
A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1101/2022.05.24.493328
Abstract: As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication. Yet, our understanding of the… read more here.
Keywords: enterovirus replication; replication organelles; replication; host protein ... See more keywords
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01388-21
Abstract: Identification of host factors involved in viral replication is an important approach in discovering viral pathogenic mechanisms and identifying potential therapeutic targets. Previously, we screened host proteins that were upregulated by EV71 infection. ABSTRACT Enterovirus… read more here.
Keywords: replication; host protein; gadd34; precursor ... See more keywords
Systems Biology of Virus-Host Protein Interactions: From Hypothesis Generation to Mechanisms of Replication and Pathogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of virology"
DOI: 10.1146/annurev-virology-100520-011851
Abstract: As obligate intracellular parasites, all viruses must co-opt cellular machinery to facilitate their own replication. Viruses often co-opt these cellular pathways and processes through physical interactions between viral and host proteins. In addition to facilitating… read more here.
Keywords: virus host; host; biology; host protein ... See more keywords
Abstract 4891: Hepatitis B virus remodels host protein interaction networks to generate distinct cellular dependencies
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4891
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer death worldwide. Advanced HCC has proven particularly difficult to treat because of a scarcity of clear genetic drivers of cancer progression; thus, there are currently… read more here.
Keywords: hepatitis; hbv; host protein; hepatitis virus ... See more keywords
Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007745
Abstract: Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus (Flaviviridae), is a causative agent of a severe neuroinfection. Recently, several flaviviruses have been shown to interact with host protein synthesis. In order to determine… read more here.
Keywords: borne encephalitis; host protein; tick borne; host ... See more keywords
LGCA-VHPPI: A local-global residue context aware viral-host protein-protein interaction predictor
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270275
Abstract: Viral-host protein protein interaction (PPI) analysis is essential to decode the molecular mechanism of viral pathogen and host immunity processes which eventually help to control viral diseases and optimize therapeutics. The state-of-the-art viral-host PPI predictor… read more here.
Keywords: interaction; lgca vhppi; host protein; viral host ... See more keywords
The Landscape of Virus-Host Protein–Protein Interaction Databases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.827742
Abstract: Knowledge of virus-host interactomes has advanced exponentially in the last decade by the use of high-throughput screening technologies to obtain a more comprehensive landscape of virus-host protein–protein interactions. In this article, we present a systematic… read more here.
Keywords: protein protein; host protein; virus host; virus ... See more keywords