HIV-1 usurps transcription start site heterogeneity of host RNA polymerase II to maximize replication fitness.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2305103120
Abstract: HIV-1 relies on host RNA polymeraseII (Pol II) to transcribe its genome and uses multiple transcription start sites (TSS), including three consecutive guanosines located near the U3-R junction, to generate transcripts containing three, two, and… read more here.
Keywords: replication fitness; hiv; transcription; replication ... See more keywords
2-5A-Mediated decay (2-5AMD): from antiviral defense to control of host RNA
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2023.2181308
Abstract: Abstract Mammalian cells are exquisitely sensitive to the presence of double-stranded RNA (dsRNA), a molecule that they interpret as a signal of viral presence requiring immediate attention. Upon sensing dsRNA cells activate the innate immune… read more here.
Keywords: 5amd antiviral; decay 5amd; rna; mediated decay ... See more keywords
Comprehensive Characterization of Transcriptional Activity during Influenza A Virus Infection Reveals Biases in Cap-Snatching of Host RNA Sequences
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01720-19
Abstract: Infection with influenza A virus (IAV) infection is responsible for an estimated 500,000 deaths and up to 5 million cases of severe respiratory illness each year. In this study, we looked at human primary immune… read more here.
Keywords: cap; infection; host rna; virus ... See more keywords
A Novel Anphevirus in Aedes albopictus Mosquitoes Is Distributed Worldwide and Interacts with the Host RNA Interference Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12111264
Abstract: The Asian tiger mosquito Aedes albopictus is a competent vector for several human arboviruses including dengue, chikungunya and Zika viruses. Mosquitoes also harbor insect-specific viruses (ISVs) that may modulate host physiology and potentially affect the… read more here.
Keywords: rna interference; novel anphevirus; physiology; host rna ... See more keywords
Dancing with the Devil: A Review of the Importance of Host RNA-Binding Proteins to Alphaviral RNAs during Infection
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15010164
Abstract: Alphaviruses are arthropod-borne, single-stranded positive sense RNA viruses that rely on the engagement of host RNA-binding proteins to efficiently complete the viral lifecycle. Because of this reliance on host proteins, the identification of host/pathogen interactions… read more here.
Keywords: rna binding; infection; binding proteins; host rna ... See more keywords