Rapid and quantitative evaluation of vaccinia virus‐induced host shutoff using newly generated cell lines stably expressing secreted Gaussia luciferase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27773
Abstract: Host shutoff, characterized by a global decline of cellular protein synthesis, is commonly observed in many viral infections, including vaccinia virus (VACV). Classic methods measuring host shutoff include the use of radioactive or nonradioactive probes… read more here.
Keywords: host shutoff; induced host; shutoff; cell lines ... See more keywords
Going against the Tide: Selective Cellular Protein Synthesis during Virally Induced Host Shutoff
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00071-17
Abstract: ABSTRACT Many viral infections cause host shutoff, a state in which host protein synthesis is globally inhibited. Emerging evidence from vaccinia and influenza A virus infections indicates that subsets of cellular proteins are resistant to… read more here.
Keywords: protein synthesis; host; host shutoff;
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner
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DOI: 10.1128/mbio.03433-23
Abstract: ABSTRACT Viruses have evolved intricate mechanisms to evade host antiviral responses and exploit cellular resources by manipulating the expression profile of host genes. During infection, viruses encode proteins with shutoff activity to globally inhibit host… read more here.
Keywords: host shutoff; infectious bursal; host; infection ... See more keywords
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74489
Abstract: The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key… read more here.
Keywords: cell; antibody dependent; cov host; host shutoff ... See more keywords