Mitochondrial haplotype of the host stromal microenvironment alters metastasis in a non-cell autonomous manner.
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DOI: 10.1158/0008-5472.can-19-2481
Abstract: Mitochondria contribute to tumor growth through multiple metabolic pathways, regulation of extracellular pH, calcium signaling, and apoptosis. Using the Mitochondrial Nuclear Exchange (MNX) mouse models, which pair nuclear genomes with different mitochondrial genomes, we previously… read more here.
Keywords: host stromal; stromal microenvironment; haplotype host; mitochondrial haplotype ... See more keywords