Medicinal chemistry strategies toward host targeting antiviral agents
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DOI: 10.1002/med.21664
Abstract: Abstract Directâacting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and have been demonstrated to be very successful in combating viral infections in clinic. However, DAAs suffer from several inherent limitations, including… read more here.
Keywords: medicinal chemistry; chemistry; viral infections; antiviral agents ... See more keywords
Direct-Acting Antivirals and Host-Targeting Approaches against Enterovirus B Infections: Recent Advances
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DOI: 10.3390/ph16020203
Abstract: Enterovirus B (EV-B)-related diseases, which can be life threatening in high-risk populations, have been recognized as a serious health problem, but their clinical treatment is largely supportive, and no selective antivirals are available on the… read more here.
Keywords: targeting approaches; host targeting; antivirals host; acting antivirals ... See more keywords
A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses
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DOI: 10.3390/v14050928
Abstract: New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the universal host factors necessary for viral replication are the most promising approach, with… read more here.
Keywords: emerging emerging; host targeting; strategy; emerging viruses ... See more keywords
Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus
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DOI: 10.3390/v15040981
Abstract: Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cycle; as… read more here.
Keywords: daas; host targeting; direct acting; host ... See more keywords