Finding host targets for HIV therapy
Sign Up to like & getrecommendations! Published in 2017 at "Nature Genetics"
DOI: 10.1038/ng.3777
Abstract: A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular… read more here.
Keywords: host targets; targets hiv; finding host; hiv therapy ... See more keywords
Global fungal-host interactome mapping identifies host targets of candidalysin
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46141-x
Abstract: Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we performed a high-throughput enhanced yeast two-hybrid… read more here.
Keywords: candidalysin; dna damage; host targets; targets candidalysin ... See more keywords
Host targets of candidalysin
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013284
Abstract: Candida albicans is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. C. albicans hyphae secrete candidalysin,… read more here.
Keywords: host targets; targets candidalysin;